Systems approach reveals distinct and shared signaling networks of the four PGE2 receptors in T cells
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DOI: 10.1126/scisignal.abc8579
Abstract: Description PGE2 receptors elicit shared, receptor-specific, and cell type–specific downstream signaling in T cells. PGE2 signaling networks The lipid mediator PGE2 suppresses antitumor immunity by activating its four related GPCRs on T cells. Lone et… read more here.
Keywords: pge2 receptors; receptor specific; pge2; signaling networks ... See more keywords
Pharmacological modulation of prostaglandin E2 (PGE2) EP receptors improves cardiomyocyte function under hyperglycemic conditions
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DOI: 10.14814/phy2.15212
Abstract: Type 2 diabetes (T2D) affects >30 million Americans and nearly 70% of individuals with T2D will die from cardiovascular disease (CVD). Circulating levels of the inflammatory signaling lipid, prostaglandin E2 (PGE2), are elevated in the… read more here.
Keywords: function; pge2; prostaglandin pge2; pge2 receptors ... See more keywords