Autophagy in Endothelial Cells Regulates Their Hematopoiesis Supporting Ability
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DOI: 10.1182/blood-2019-122227
Abstract: Background: Endothelial cells(ECs) serve as an instructive platform to support hematopoietic stem cells(HSCs) for homeostasis, however the underlying mechanism by which ECs regulate HSCs remains unclear. In humans, poor graft function(PGF) is characterized by pancytopenia… read more here.
Keywords: hematopoiesis; ecs; pgf patients; autophagy ... See more keywords
Prophylactic oral NAC reduced poor hematopoietic reconstitution by improving endothelial cells after haploidentical transplantation.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2018029454
Abstract: Poor graft function (PGF) and prolonged isolated thrombocytopenia (PT) remain life-threatening complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Endothelial cells (ECs) play a crucial role in regulating hematopoiesis in the bone marrow (BM) microenvironment.… read more here.
Keywords: ecs; hsct; pgf; reconstitution ... See more keywords