Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets
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DOI: 10.1186/s12974-018-1305-3
Abstract: BackgroundProstaglandins are products of the cyclooxygenase pathway, which is implicated in Parkinson’s disease (PD). Limited knowledge is available on mechanisms by which prostaglandins contribute to PD neurodegeneration. To address this gap, we focused on the… read more here.
Keywords: pgj2; like pathology; neuroinflammation; pathology ... See more keywords
Effect of 15-Deoxy-∆12,14-prostaglandin J2 Nanocapsules on Inflammation and Bone Regeneration in a Rat Bone Defect Model
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Medical Journal"
DOI: 10.4103/0366-6999.198924
Abstract: Background: 15-Deoxy-[INCREMENT]12,14-prostaglandin J2 (15d-PGJ2), one of the major metabolites from prostaglandin D2 in arachidonic acid metabolic pathway, has potential anti-inflammatory properties. The objective of this study was to explore the effects of 15d-PGJ2-loaded poly(D,L-lactide-co-glycolide) nanocapsules… read more here.
Keywords: bone regeneration; 15d pgj2; pgj2; bone defect ... See more keywords