Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28887
Abstract: Phosphoglycerate kinase 1 (PGK1) is an important enzyme in the metabolic glycolysis pathway. In this study, we observed a significant overexpression of PGK1 in liver cancer tissues and a negative correlation between PGK1 expression and… read more here.
Keywords: pgk1; cancer cell; cancer; liver cancer ... See more keywords
PGK1 : An Essential Player in Modulating Tumor Metabolism.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1558-4_4
Abstract: Phosphoglycerate kinase 1 (PGK1) is the first enzyme in glycolysis to generate a molecule of ATP in the conversion of 1,3-bisphosphoglycerate (1,3-BPG) to 3-phosphoglycerate (3-PG). In addition to the role of glycolysis, PGK-1 acts as… read more here.
Keywords: essential player; player modulating; pgk1; pgk1 essential ... See more keywords
Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.09.007
Abstract: DNA replication is initiated by assembly of the kinase cell division cycle 7 (CDC7) with its regulatory activation subunit, activator of S-phase kinase (ASK), to activate DNA helicase. However, the mechanism underlying regulation of CDC7-ASK… read more here.
Keywords: cdc7; dna; dna replication; pgk1 ... See more keywords
Protein kinase activity of the glycolytic enzyme PGK1 regulates autophagy to promote tumorigenesis
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1313945
Abstract: ABSTRACT Macroautophagy/autophagy is a cellular defense response to stress conditions and is crucial for cell homeostasis maintenance. However, the precise mechanism underlying autophagy initiation, especially in response to glutamine deprivation and hypoxia, is yet to… read more here.
Keywords: pgk1; glycolytic enzyme; activity; protein kinase ... See more keywords
The Discovery of Novel PGK1 Activators as Apoptotic Inhibiting and Neuroprotective Agents
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.877706
Abstract: Stroke is the second leading cause of death worldwide and the leading cause of long-term disability that seriously endangers health and quality of human life. Tissue-type fibrinogen activator is currently the only drug approved by… read more here.
Keywords: activators apoptotic; discovery novel; novel pgk1; pgk1 ... See more keywords
Prognosis and Immunological Characteristics of PGK1 in Lung Adenocarcinoma: A Systematic Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14215228
Abstract: Simple Summary Immunotherapy has become a major treatment for lung adenocarcinoma. Better understanding of the tumor microenvironment (TME) in lung adenocarcinoma is needed in order to better treat it with this type of therapy. In… read more here.
Keywords: lung adenocarcinoma; immunological characteristics; pgk1; tumor ... See more keywords
Cerebroventricular Injection of Pgk1 Attenuates MPTP-Induced Neuronal Toxicity in Dopaminergic Cells in Zebrafish Brain in a Glycolysis-Independent Manner
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084150
Abstract: Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons. While extracellular Pgk1 (ePgk1) is reported to promote neurite outgrowth, it remains unclear if it can affect the survival of dopaminergic cells. To address… read more here.
Keywords: mptp treated; brain; dopamine; pgk1 ... See more keywords
Gemcitabine–Paclitaxel Chemotherapy for Patients with Advanced Urothelial Cancer Refractory to Cisplatin-Based Chemotherapy: Predictive Role of PGK1 for Treatment Response to Cytotoxic Chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012119
Abstract: An investigation of alternatives to immune checkpoint inhibitors for advanced urothelial cancer (aUC), with biologic information, is urgently needed. Clinical data for 53 patients who received gemcitabine–paclitaxel therapy (GP) as 2nd-line chemotherapy for aUC refractory… read more here.
Keywords: pgk1; advanced urothelial; line; response ... See more keywords