Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28887
Abstract: Phosphoglycerate kinase 1 (PGK1) is an important enzyme in the metabolic glycolysis pathway. In this study, we observed a significant overexpression of PGK1 in liver cancer tissues and a negative correlation between PGK1 expression and… read more here.
Keywords: pgk1; cancer cell; cancer; liver cancer ... See more keywords
PGK1 : An Essential Player in Modulating Tumor Metabolism.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1558-4_4
Abstract: Phosphoglycerate kinase 1 (PGK1) is the first enzyme in glycolysis to generate a molecule of ATP in the conversion of 1,3-bisphosphoglycerate (1,3-BPG) to 3-phosphoglycerate (3-PG). In addition to the role of glycolysis, PGK-1 acts as… read more here.
Keywords: essential player; player modulating; pgk1; pgk1 essential ... See more keywords
Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.09.007
Abstract: DNA replication is initiated by assembly of the kinase cell division cycle 7 (CDC7) with its regulatory activation subunit, activator of S-phase kinase (ASK), to activate DNA helicase. However, the mechanism underlying regulation of CDC7-ASK… read more here.
Keywords: cdc7; dna; dna replication; pgk1 ... See more keywords
Isochlorogenic Acid A Attenuated Periodontitis by Inhibiting Inflammation via ACE/PGK1/STAT1 Signaling.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c13299
Abstract: The purpose of the present study was to evaluate the effect of isochlorogenic acid A (IAA) on periodontitis and explore its potential mechanism. A ligature/LPS procedure was employed to induce periodontitis in rats. LPS-induced HPDLF… read more here.
Keywords: periodontitis; ace pgk1; pgk1 stat1; pgk1 ... See more keywords
Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51232-w
Abstract: Protein post-translational modifications (PTMs) are crucial for cancer cells to adapt to hypoxia; however, the functional significance of lysine crotonylation (Kcr) in hypoxia remains unclear. Herein we report a quantitative proteomics analysis of global crotonylome… read more here.
Keywords: crotonylation; cancer; hypoxia; downregulation pgk1 ... See more keywords
PGK1: A Common Biomarker and Therapeutic Target Linking Sarcopenia and Osteoporosis Through Fibroblast‐Mediated Pathways
Sign Up to like & getrecommendations! Published in 2025 at "IET Systems Biology"
DOI: 10.1049/syb2.70037
Abstract: ABSTRACT Sarcopenia and osteoporosis share pathophysiological links, but their co‐occurrence mechanisms remain unclear. This study aimed to identify molecular mediators of their co‐development using bioinformatics. Datasets for sarcopenia (GSE56815) and osteoporosis (GSE9103) were retrieved from… read more here.
Keywords: sarcopenia osteoporosis; analysis; pgk1; osteoporosis ... See more keywords
Protein kinase activity of the glycolytic enzyme PGK1 regulates autophagy to promote tumorigenesis
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1313945
Abstract: ABSTRACT Macroautophagy/autophagy is a cellular defense response to stress conditions and is crucial for cell homeostasis maintenance. However, the precise mechanism underlying autophagy initiation, especially in response to glutamine deprivation and hypoxia, is yet to… read more here.
Keywords: pgk1; glycolytic enzyme; activity; protein kinase ... See more keywords
Pgk1 activation restores endothelial metabolic homeostasis to alleviate vascular aging and atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Cardiovascular Diabetology"
DOI: 10.1186/s12933-025-02976-2
Abstract: Terazosin (TZ), a well-known antagonist of the α1-adrenergic receptor (α1-AR), has demonstrated protective effects on vascular endothelial cells (ECs) and reduced vascular stiffness in clinical studies. Endothelial dysfunction and oxidative stress are central drivers of… read more here.
Keywords: atherosclerosis; pgk1; pgk1 activation; aging atherosclerosis ... See more keywords
The Discovery of Novel PGK1 Activators as Apoptotic Inhibiting and Neuroprotective Agents
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.877706
Abstract: Stroke is the second leading cause of death worldwide and the leading cause of long-term disability that seriously endangers health and quality of human life. Tissue-type fibrinogen activator is currently the only drug approved by… read more here.
Keywords: activators apoptotic; discovery novel; novel pgk1; pgk1 ... See more keywords
Prognosis and Immunological Characteristics of PGK1 in Lung Adenocarcinoma: A Systematic Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14215228
Abstract: Simple Summary Immunotherapy has become a major treatment for lung adenocarcinoma. Better understanding of the tumor microenvironment (TME) in lung adenocarcinoma is needed in order to better treat it with this type of therapy. In… read more here.
Keywords: lung adenocarcinoma; immunological characteristics; pgk1; tumor ... See more keywords
Cerebroventricular Injection of Pgk1 Attenuates MPTP-Induced Neuronal Toxicity in Dopaminergic Cells in Zebrafish Brain in a Glycolysis-Independent Manner
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084150
Abstract: Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons. While extracellular Pgk1 (ePgk1) is reported to promote neurite outgrowth, it remains unclear if it can affect the survival of dopaminergic cells. To address… read more here.
Keywords: mptp treated; brain; dopamine; pgk1 ... See more keywords