Progesterone receptor membrane component 1 reduces cardiac steatosis and lipotoxicity via activation of fatty acid oxidation and mitochondrial respiration
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DOI: 10.1038/s41598-021-88251-2
Abstract: Obesity is implicated in cardiovascular disease and heart failure. When fatty acids are transported to and not adequately oxidized in cardiac cells, they accumulate, causing lipotoxicity in the heart. Since hepatic progesterone receptor membrane component… read more here.
Keywords: pgrmc1; heart; pgrmc1 mice; lipotoxicity ... See more keywords