LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "pgrn" as a keyword



Photo by john_cameron from unsplash

Progranulin regulates neurogenesis in the developing vertebrate retina

Sign Up to like & get
recommendations! Published in 2017 at "Developmental Neurobiology"

DOI: 10.1002/dneu.22499

Abstract: We evaluated the expression and function of the microglia‐specific growth factor, Progranulin‐a (Pgrn‐a) during developmental neurogenesis in the embryonic retina of zebrafish. At 24 hpf pgrn‐a is expressed throughout the forebrain, but by 48 hpf… read more here.

Keywords: cell; cell cycle; progranulin; pgrn ... See more keywords
Photo by boxedwater from unsplash

Regulation of cathepsin D activity by the FTLD protein progranulin

Sign Up to like & get
recommendations! Published in 2017 at "Acta Neuropathologica"

DOI: 10.1007/s00401-017-1719-5

Abstract: and suggest that PGRN and CTSD might function together to regulate lysosomal activities. In support of this hypothesis, granulin motifs are found in cathepsin-like cysteine proteases in plants [11, 16]. These lines of evidence led… read more here.

Keywords: pgrn ctsd; interaction pgrn; ctsd; granulin ... See more keywords
Photo by nci from unsplash

MicroRNA-1246 suppresses the metastasis of breast cancer cells by targeting the DYRK1A/PGRN axis to prevent the epithelial-mesenchymal transition.

Sign Up to like & get
recommendations! Published in 2022 at "Molecular biology reports"

DOI: 10.1007/s11033-021-07080-8

Abstract: OBJECTIVE Breast cancer is one of the most common malignant and highly heterogeneous tumors in women. MicroRNAs (miRNAs), such as miR-1246, play important roles in various types of malignant cancers, including triple-negative breast cancer (TNBC).… read more here.

Keywords: mir; breast cancer; mir 1246; pgrn ... See more keywords
Photo from wikipedia

Higher levels of progranulin in cerebrospinal fluid of patients with lymphoma and carcinoma with CNS metastasis

Sign Up to like & get
recommendations! Published in 2017 at "Journal of Neuro-Oncology"

DOI: 10.1007/s11060-017-2742-z

Abstract: Assessing central nervous system (CNS) involvement in patients with lymphoma or carcinoma is important in determining therapy and prognosis. Progranulin (PGRN) is a secreted glycosylated protein with roles in cancer growth and survival; it is… read more here.

Keywords: cns lymphoma; cns metastasis; cns; pgrn ... See more keywords
Photo by sxy_selia from unsplash

Approaches to develop therapeutics to treat frontotemporal dementia

Sign Up to like & get
recommendations! Published in 2020 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2020.107948

Abstract: Frontotemporal degeneration (FTD) is a complex disease presenting as a spectrum of clinical disorders with progressive degeneration of frontal and temporal brain cortices and extensive neuroinflammation that result in personality and behavior changes, and eventually,… read more here.

Keywords: approaches develop; therapeutics treat; pgrn levels; pgrn ... See more keywords
Photo from archive.org

Biological function analysis of monoclonal antibodies against human granulins in vitro using U251 cells as a model.

Sign Up to like & get
recommendations! Published in 2017 at "Protein expression and purification"

DOI: 10.1016/j.pep.2016.09.019

Abstract: Progranulin (PGRN), a highly glycosylated, secreted 593 amino acid precursor protein, is a multifunctional molecule that is critical for early embryogenesis, wound repair, inflammatory and tumorigenesis. PGRN can be proteolytically cleaved into seven cysteine-rich granulin… read more here.

Keywords: vitro using; monoclonal antibodies; biological function; function analysis ... See more keywords
Photo from wikipedia

Progranulin as a therapeutic target in neurodegenerative diseases.

Sign Up to like & get
recommendations! Published in 2022 at "Trends in pharmacological sciences"

DOI: 10.1016/j.tips.2021.11.015

Abstract: Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development, survival, function, and maintenance of neurons and microglia in the mammalian brain. It regulates lysosomal biogenesis, inflammation, repair, stress response, and… read more here.

Keywords: progranulin therapeutic; target neurodegenerative; pgrn; gene ... See more keywords
Photo by cdc from unsplash

Progranulin ameliorates coxsackievirus‐B3‐induced viral myocarditis by downregulating Th1 and Th17 cells

Sign Up to like & get
recommendations! Published in 2018 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2018.04.001

Abstract: ABSTRACT Viral myocarditis, which is caused by Coxsackievirus B3 (CVB3) infection, is a leading reason of sudden cardiac death in young adults. Progranulin (PGRN), a pleiotropic growth factor, has been shown to exert anti‐inflammatory function… read more here.

Keywords: viral myocarditis; th17 cells; th1 th17; pgrn ... See more keywords

Progranulin regulates the development and function of NKT2 cells through EZH2 and PLZF.

Sign Up to like & get
recommendations! Published in 2022 at "Cell death and differentiation"

DOI: 10.1038/s41418-022-00973-6

Abstract: T helper 2 (Th2) cytokine production by invariant natural killer T (iNKT) cells is involved in the development of asthma, but the regulation of Th2 cytokines in iNKT cells remains unknown. Although it is known… read more here.

Keywords: inkt; nkt2 cells; pgrn; development ... See more keywords
Photo by fakurian from unsplash

PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases

Sign Up to like & get
recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2210442120

Abstract: Significance This study carries immediate significance and novelty from following perspectives: (a) It provides the first line of in vivo and ex vivo evidence demonstrating the crucial role of PGRN in GBA1 mutation-related diseases (i.e.,… read more here.

Keywords: penetrant pgrn; gba1 mutation; brain penetrant; pgrn ... See more keywords
Photo from wikipedia

Progranulin as a therapeutic target for dementia

Sign Up to like & get
recommendations! Published in 2018 at "Expert Opinion on Therapeutic Targets"

DOI: 10.1080/14728222.2018.1487951

Abstract: ABSTRACT Introduction: Progranulin (PGRN) is an acrosomal glycoprotein that is synthesized during spermatogenesis. It is overexpressed in tumors and has anti-inflammatory properties. The protein may be cleaved into granulins which display pro-inflammatory properties. In 2006,… read more here.

Keywords: progranulin therapeutic; target dementia; therapeutic target; pgrn ... See more keywords