Progranulin deficiency promotes persistent neuroinflammation and causes regional pathology in the hippocampus following traumatic brain injury.
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DOI: 10.1002/glia.24175
Abstract: Traumatic brain injury (TBI) can be progressive and can lead to the development of a long-term complication termed chronic traumatic encephalopathy. The mechanisms underlying the progressive changes are still unknown; however, studies have suggested that… read more here.
Keywords: brain injury; mice; traumatic brain; pgrn deficient ... See more keywords
Convulsive responses to seizure-inducible drugs are exacerbated in progranulin-deficient mice
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DOI: 10.1097/wnr.0000000000001425
Abstract: Progranulin (PGRN) is a glycoprotein that is widely expressed among organs, including the central nervous system. PGRN insufficiency is involved in various neurodegenerative disorders such as frontotemporal dementia, Alzheimer’s disease, and neuronal ceroid lipofuscinosis. One… read more here.
Keywords: pgrn deficient; deficient mice; mice; seizure ... See more keywords