Low Plasma Gelsolin Concentrations in Chronic Granulomatous Disease
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DOI: 10.1007/s10753-020-01330-w
Abstract: Plasma gelsolin (pGSN) is the secreted isoform of an intracellular actin remodeling protein found in high concentrations in human plasma. Clinical studies demonstrate reduced pGSN concentrations in several disease states, including severe trauma, burns, and… read more here.
Keywords: cgd patients; pgsn; plasma gelsolin; healthy volunteers ... See more keywords
Adjunctive Recombinant Human Plasma Gelsolin for Severe Coronavirus Disease 2019 Pneumonia
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DOI: 10.1093/ofid/ofac357
Abstract: Abstract Background Excessive inflammation contributes to the morbidity and mortality of severe coronavirus disease 2019 (COVID-19) pneumonia. Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse experimental models of infectious and noninfectious inflammation. Methods… read more here.
Keywords: rhu pgsn; pneumonia; coronavirus disease; severe coronavirus ... See more keywords
Delayed Therapy with Plasma Gelsolin Improves Survival in Murine Pneumococcal Pneumonia
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DOI: 10.1093/ofid/ofx163.1215
Abstract: Abstract Background Innate immune responses contribute to successful resolution of bacterial pneumonia. Bolstering host defense with immunomodulators might be increasingly needed to improve outcomes in antibiotic-resistant infections. One candidate molecule is recombinant human plasma gelsolin… read more here.
Keywords: plasma gelsolin; pgsn; rhu pgsn; pneumonia ... See more keywords
Plasma Gelsolin Inhibits CD8+ T-cell Function and Regulates Glutathione Production to Confer Chemoresistance in Ovarian Cancer
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DOI: 10.1158/0008-5472.can-20-0788
Abstract: These findings provide new insight into pGSN-mediated immune cell dysfunction in ovarian cancer chemoresistance and demonstrate how this dysfunction can be exploited to enhance immunotherapy. Although initial treatment of ovarian cancer is successful, tumors typically… read more here.
Keywords: ovarian cancer; chemoresistance; pgsn; cd8 ... See more keywords
Longitudinal profiles of plasma gelsolin, cytokines and antibody expression predict COVID-19 severity and hospitalization outcomes
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DOI: 10.3389/fimmu.2022.1011084
Abstract: Background Prognostic markers for COVID-19 disease outcome are currently lacking. Plasma gelsolin (pGSN) is an actin-binding protein and an innate immune marker involved in disease pathogenesis and viral infections. Here, we demonstrate the utility of… read more here.
Keywords: predict covid; covid severity; covid; pgsn ... See more keywords
Plasma Gelsolin Reinforces the Diagnostic Value of FGF-21 and GDF-15 for Mitochondrial Disorders
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DOI: 10.3390/ijms22126396
Abstract: Mitochondrial disorders (MD) comprise a group of heterogeneous clinical disorders for which non-invasive diagnosis remains a challenge. Two protein biomarkers have so far emerged for MD detection, FGF-21 and GDF-15, but the identification of additional… read more here.
Keywords: plasma gelsolin; fgf; mitochondrial disorders; pgsn ... See more keywords