Concurrent Preimplantation Genetic Testing and Competence Assessment of Human Embryos by Transcriptome Sequencing
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DOI: 10.1002/advs.202309817
Abstract: Preimplantation genetic testing (PGT) can minimize the risk of birth defects. However, the accuracy and applicability of routine PGT is confounded by uneven genome coverage and high allele drop‐out rate from existing single‐cell whole genome… read more here.
Keywords: competence assessment; pgt; preimplantation genetic; competence ... See more keywords
Offering preimplantation genetic testing for monogenic disorders (PGT-M) for conditions with reduced penetrance or variants of uncertain significance: Ethical insight from U.S. laboratory genetic counselors.
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DOI: 10.1002/jgc4.1482
Abstract: Preimplantation genetic testing for monogenic disorders (PGT-M) was originally developed to identify embryos affected with serious childhood-onset disorders, but its use has recently broadened. Guidance on the use of PGT-M in the United States (U.S.)… read more here.
Keywords: genetic counselors; pgt; reduced penetrance; laboratory ... See more keywords
Preimplantation genetic testing for polygenic disorders: Viewpoints of reproductive genetic counselors and reproductive endocrinology and infertility specialists in the United States
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DOI: 10.1002/jgc4.70072
Abstract: The purpose of this study was to assess awareness of preimplantation genetic testing (PGT) for polygenic disorders (PGT‐P) and viewpoints surrounding PGT among reproductive genetic counselors (GCs) and reproductive endocrinology infertility physicians (REIs) in the… read more here.
Keywords: pgt; preimplantation genetic; reproductive genetic; polygenic disorders ... See more keywords
Analysis of PGT‐M and PGT‐SR outcomes at a Canadian fertility clinic
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DOI: 10.1002/pd.5496
Abstract: Outcomes from in vitro fertilization (IVF)/intrauterine insemination (ICSI) cycles for patients who underwent preimplantation genetic testing for monogenic/single gene (PGT‐M) and structural chromosome rearrangements (PGT‐SR) patients were reviewed. Patients pursuing PGT‐M and PGT‐SR often do… read more here.
Keywords: pgt; pgt outcomes; pgt pgt; analysis pgt ... See more keywords
ISPD 2021 Debate - All IVF cycles should involve pre-implantation genetic testing to improve fetal health and pregnancy outcomes.
Sign Up to like & getrecommendations! Published in 2022 at "Prenatal diagnosis"
DOI: 10.1002/pd.6156
Abstract: For three decades, couples at increased risk for a genetic disorder have been offered preimplantation genetic testing (PGT). Simultaneously, PGT for aneuploidy (PGT-A) to improve in vitro fertilization (IVF) outcomes was introduced, but evidence of… read more here.
Keywords: ispd 2021; debate; ivf cycles; genetic testing ... See more keywords
How 1 h of abstinence improves sperm quality and increases embryo euploidy rate after PGT-A: a study on 106 sibling biopsied blastocysts
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-019-01533-7
Abstract: PurposeThe aim of our study was to evaluate the influence of different ejaculatory abstinence time frames (several days versus 1 h) on semen parameters, blastocysts ploidy rate, and clinical results in assisted reproduction cycles on sibling… read more here.
Keywords: quality; pgt; group; study ... See more keywords
Preimplantation genetic testing and chances of a healthy live birth amongst recipients of fresh donor oocytes in the United States
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DOI: 10.1007/s10815-020-01874-8
Abstract: Purpose To evaluate if preimplantation genetic testing (PGT) improves the odds of a healthy live birth amongst recipients of fresh donor oocytes. Methods We performed a retrospective cohort study including in vitro fertilization cycles of… read more here.
Keywords: donor oocytes; birth; pgt; fresh donor ... See more keywords
Analysis of IVF live birth outcomes with and without preimplantation genetic testing for aneuploidy (PGT-A): UK Human Fertilisation and Embryology Authority data collection 2016–2018
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-021-02349-0
Abstract: To examine the live birth and other outcomes reported with and without preimplantation genetic testing for aneuploidy (PGT-A) in the United Kingdom (UK) Human Embryology and Fertilization Authority (HFEA) data collection. A retrospective cohort analysis… read more here.
Keywords: non pgt; embryology; pgt; 2016 2018 ... See more keywords
Mapping ethical, legal, and social implications (ELSI) of preimplantation genetic testing (PGT)
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DOI: 10.1007/s10815-024-03076-y
Abstract: Preimplantation Genetic Testing (PGT) has attracted considerable ethical, legal, and social scrutiny, but academic debate often fails to reflect clinical realities. Addressing this disconnect, a review of 506 articles from 1999 to 2019 across humanities… read more here.
Keywords: pgt; preimplantation genetic; ethical legal; research ... See more keywords
Development of Progesterone Oily Suspension Using Moringa Oil and Neusilin US2
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DOI: 10.1007/s12247-020-09529-y
Abstract: The objective of the present study was to screen oils and suspending agents for the formulation of novel progesterone (PGT) suspension, demonstrating improved solubility, drug release, stability, and non-allergenicity. Presumably, formulated novel PGT suspensions could… read more here.
Keywords: pgt; moringa oil; oil; neusilin us2 ... See more keywords
Maternal estradiol and progesterone concentrations among singleton spontaneous pregnancies during the first trimester
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DOI: 10.1007/s40618-018-0961-6
Abstract: BackgroundPregnancy hormonal milieu represents a crucial determinant of fetal outcome. We aim to determine 17β-estradiol (E2) and progesterone (PGT) concentrations in spontaneous pregnancies during the first trimester. In addition, we aim to determine E2 concentrations… read more here.
Keywords: estradiol progesterone; pgt; pregnancies first; first trimester ... See more keywords