Offering preimplantation genetic testing for monogenic disorders (PGT-M) for conditions with reduced penetrance or variants of uncertain significance: Ethical insight from U.S. laboratory genetic counselors.
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DOI: 10.1002/jgc4.1482
Abstract: Preimplantation genetic testing for monogenic disorders (PGT-M) was originally developed to identify embryos affected with serious childhood-onset disorders, but its use has recently broadened. Guidance on the use of PGT-M in the United States (U.S.)… read more here.
Keywords: genetic counselors; pgt; reduced penetrance; laboratory ... See more keywords
Analysis of PGT‐M and PGT‐SR outcomes at a Canadian fertility clinic
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DOI: 10.1002/pd.5496
Abstract: Outcomes from in vitro fertilization (IVF)/intrauterine insemination (ICSI) cycles for patients who underwent preimplantation genetic testing for monogenic/single gene (PGT‐M) and structural chromosome rearrangements (PGT‐SR) patients were reviewed. Patients pursuing PGT‐M and PGT‐SR often do… read more here.
Keywords: pgt; pgt outcomes; pgt pgt; analysis pgt ... See more keywords
ISPD 2021 Debate - All IVF cycles should involve pre-implantation genetic testing to improve fetal health and pregnancy outcomes.
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DOI: 10.1002/pd.6156
Abstract: For three decades, couples at increased risk for a genetic disorder have been offered preimplantation genetic testing (PGT). Simultaneously, PGT for aneuploidy (PGT-A) to improve in vitro fertilization (IVF) outcomes was introduced, but evidence of… read more here.
Keywords: ispd 2021; debate; ivf cycles; genetic testing ... See more keywords
How 1 h of abstinence improves sperm quality and increases embryo euploidy rate after PGT-A: a study on 106 sibling biopsied blastocysts
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DOI: 10.1007/s10815-019-01533-7
Abstract: PurposeThe aim of our study was to evaluate the influence of different ejaculatory abstinence time frames (several days versus 1 h) on semen parameters, blastocysts ploidy rate, and clinical results in assisted reproduction cycles on sibling… read more here.
Keywords: quality; pgt; group; study ... See more keywords
Preimplantation genetic testing and chances of a healthy live birth amongst recipients of fresh donor oocytes in the United States
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DOI: 10.1007/s10815-020-01874-8
Abstract: Purpose To evaluate if preimplantation genetic testing (PGT) improves the odds of a healthy live birth amongst recipients of fresh donor oocytes. Methods We performed a retrospective cohort study including in vitro fertilization cycles of… read more here.
Keywords: donor oocytes; birth; pgt; fresh donor ... See more keywords
Analysis of IVF live birth outcomes with and without preimplantation genetic testing for aneuploidy (PGT-A): UK Human Fertilisation and Embryology Authority data collection 2016–2018
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DOI: 10.1007/s10815-021-02349-0
Abstract: To examine the live birth and other outcomes reported with and without preimplantation genetic testing for aneuploidy (PGT-A) in the United Kingdom (UK) Human Embryology and Fertilization Authority (HFEA) data collection. A retrospective cohort analysis… read more here.
Keywords: non pgt; embryology; pgt; 2016 2018 ... See more keywords
Development of Progesterone Oily Suspension Using Moringa Oil and Neusilin US2
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DOI: 10.1007/s12247-020-09529-y
Abstract: The objective of the present study was to screen oils and suspending agents for the formulation of novel progesterone (PGT) suspension, demonstrating improved solubility, drug release, stability, and non-allergenicity. Presumably, formulated novel PGT suspensions could… read more here.
Keywords: pgt; moringa oil; oil; neusilin us2 ... See more keywords
Maternal estradiol and progesterone concentrations among singleton spontaneous pregnancies during the first trimester
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DOI: 10.1007/s40618-018-0961-6
Abstract: BackgroundPregnancy hormonal milieu represents a crucial determinant of fetal outcome. We aim to determine 17β-estradiol (E2) and progesterone (PGT) concentrations in spontaneous pregnancies during the first trimester. In addition, we aim to determine E2 concentrations… read more here.
Keywords: estradiol progesterone; pgt; pregnancies first; first trimester ... See more keywords
Effects of PGT-A on Pregnancy Outcomes for Young Women Having One Previous Miscarriage with Genetically Abnormal Products of Conception
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DOI: 10.1007/s43032-021-00542-1
Abstract: In this retrospective study, the effect of preimplantation genetic testing for aneuploidy (PGT-A) was evaluated in women younger than 38 years with a history of one prior miscarriage and embryonic chromosomal abnormalities were detected in… read more here.
Keywords: pregnancy; products conception; pgt; miscarriage ... See more keywords
Preimplantation genetic testing for aneuploidy is cost-effective, shortens treatment time, and reduces the risk of failed embryo transfer and clinical miscarriage.
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DOI: 10.1016/j.fertnstert.2018.06.021
Abstract: OBJECTIVE To determine if preimplantation genetic testing for aneuploidy (PGT-A) is cost-effective for patients undergoing in vitro fertilization (IVF). DESIGN Decision analytic model comparing costs and clinical outcomes of two strategies: IVF with and without PGT-A.… read more here.
Keywords: treatment; pgt; time; failed embryo ... See more keywords
Prognostic role of preimplantation genetic testing for aneuploidy in medically indicated fertility preservation.
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DOI: 10.1016/j.fertnstert.2019.09.040
Abstract: OBJECTIVE To investigate the use of preimplantation genetic testing for aneuploidy (PGT-A) among patients pursuing embryo banking (EB) for medically indicated fertility preservation (FP). DESIGN Retrospective cohort. SETTING University-affiliated fertility center. PATIENTS All patients who… read more here.
Keywords: genetic testing; pgt; testing aneuploidy; preimplantation genetic ... See more keywords