Clinical Implications of Pharmacogenomic Testing in the Real World-Insights From a Pediatric Program.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2021.10467
Abstract: Pharmacogenomics aims to improve medication safety and dosing by incorporating the guidance of patients’ genetic information into treatment decisions. While pharmacogenomic (PGx) testing has become more widely available and less costly, its use in routine… read more here.
Keywords: information; pgx; treatment; drug ... See more keywords
Confirmatory DPYD Testing in Patients Receiving Fluoropyrimidines who are Suspected DPYD Variant Carriers Based on a Genetic Data Repository.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2936
Abstract: Using pharmacogenetics (PGx) to inform clinical decision making can benefit patients but clinical use of PGx testing has been limited. Existing genetics data obtained in the course of research could be used to identify patients… read more here.
Keywords: dpyd; dpyd testing; data repository; suspected dpyd ... See more keywords
A National Study Among Diverse US Populations of Exposure to Prescription Medications with Evidence‐Based Pharmacogenomic Information
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3617
Abstract: Tailoring pharmacogenomic (PGx) implementation to diverse populations is vital to promoting health equity. We assessed prescriptions for medications with potentially actionable PGx information to identify patient characteristics associated with differential PGx medication exposure. We analyzed… read more here.
Keywords: information; diverse populations; pgx; prescription ... See more keywords
Current State of Pharmacogenomic Implementation Into Care for Persons With Cystic Fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.71229
Abstract: Cystic fibrosis (CF) was once a fatal disease of childhood, but with advances in combination CFTR modulator therapies, life expectancy for persons with CF (PwCF) has increased. Despite remarkable improvements in life expectancy, CF is… read more here.
Keywords: care; cystic fibrosis; cff accap; pgx ... See more keywords
Preparation of PGX-dried gum arabic and its loading with coQ10 by adsorptive precipitation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Supercritical Fluids"
DOI: 10.1016/j.supflu.2019.104662
Abstract: Abstract The Pressurized Gas eXpanded (PGX) liquid technology was developed for simultaneously drying and purifying high molecular weight biopolymers, resulting in nano/micro-sized powders with large surface areas that can be loaded with various bioactives. The… read more here.
Keywords: preparation pgx; pgx; adsorptive precipitation; dried gum ... See more keywords
49 Combinatorial Pharmacogenomics to Guide Treatment Selection for Major Depressive Disorder: A Large, Blinded, Randomized Controlled Trial
Sign Up to like & getrecommendations! Published in 2019 at "CNS Spectrums"
DOI: 10.1017/s1092852919000415
Abstract: Abstract Background Major depressive disorder (MDD) is a leading cause of disease burden worldwide, with lifetime prevalence in the United States of 17%. Here we present the results of the first prospective, large-scale, patient- and… read more here.
Keywords: care; response; arm; pgx ... See more keywords
What are the barriers and facilitators to the implementation of pharmacogenomics in mental health settings? A theory-based systematic review
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Pharmacy Practice"
DOI: 10.1093/ijpp/riae013.028
Abstract: Prescribing of psychotropic medicines is largely led by a trial-and-error approach. Treatment inefficacy, side effects and poor adherence are common challenges.[1] Pharmacogenomics (PGx) studies how genetic variability influences medication response. PGx Testing (PGxT) can identify… read more here.
Keywords: mental health; review; health settings; pgx ... See more keywords
Implementation of Pharmacogenomics- Where are we now?
Sign Up to like & getrecommendations! Published in 2022 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15591
Abstract: Pharmacogenomics (PGx), examining the effect of genetic variation on interpatient variation in drug disposition and response, has been widely studied for several decades. However, as cost, as well as turnaround time associated with PGx testing,… read more here.
Keywords: pharmacology; pgx testing; implementation pharmacogenomics; pgx ... See more keywords
Retrospective Review of Pharmacogenetic Testing at an Academic Children’s Hospital
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DOI: 10.1111/cts.12895
Abstract: There is limited evidence to support pharmacogenetic (PGx) testing in children. We conducted a retrospective review of PGx testing among 452 patients at an academic children’s hospital to determine the potential utility of PGx in… read more here.
Keywords: pgx; gene drug; drug; retrospective review ... See more keywords
Perceptions of pharmacogenetic exceptionalism and the implications for clinical management within an electronic health record
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DOI: 10.1111/cts.13360
Abstract: Genetic exceptionalism refers to a concept that genetic information is distinct from other health data and therefore should have additional safety guards in place. The objective of this study was to establish perceptions of pharmacogenetic… read more here.
Keywords: health; exceptionalism; management; pgx ... See more keywords
A Randomized Hybrid‐Effectiveness Trial Comparing Pharmacogenomics (PGx) to Standard Care: The PGx Applied to Chronic Pain Treatment in Primary Care (PGx‐ACT) Trial
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Translational Science"
DOI: 10.1111/cts.70154
Abstract: This trial aimed to identify the effects of providing pharmacogenomic (PGx) results and recommendations for patients with chronic pain treated in primary care practices compared to standard care. An open‐label, prospective, largely virtual, type‐2 hybrid… read more here.
Keywords: standard care; care pgx; pain; trial ... See more keywords