Clinical Implications of Pharmacogenomic Testing in the Real World-Insights From a Pediatric Program.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2021.10467
Abstract: Pharmacogenomics aims to improve medication safety and dosing by incorporating the guidance of patients’ genetic information into treatment decisions. While pharmacogenomic (PGx) testing has become more widely available and less costly, its use in routine… read more here.
Keywords: information; pgx; treatment; drug ... See more keywords
Confirmatory DPYD Testing in Patients Receiving Fluoropyrimidines who are Suspected DPYD Variant Carriers Based on a Genetic Data Repository.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2936
Abstract: Using pharmacogenetics (PGx) to inform clinical decision making can benefit patients but clinical use of PGx testing has been limited. Existing genetics data obtained in the course of research could be used to identify patients… read more here.
Keywords: dpyd; dpyd testing; data repository; suspected dpyd ... See more keywords
Preparation of PGX-dried gum arabic and its loading with coQ10 by adsorptive precipitation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Supercritical Fluids"
DOI: 10.1016/j.supflu.2019.104662
Abstract: Abstract The Pressurized Gas eXpanded (PGX) liquid technology was developed for simultaneously drying and purifying high molecular weight biopolymers, resulting in nano/micro-sized powders with large surface areas that can be loaded with various bioactives. The… read more here.
Keywords: preparation pgx; pgx; adsorptive precipitation; dried gum ... See more keywords
49 Combinatorial Pharmacogenomics to Guide Treatment Selection for Major Depressive Disorder: A Large, Blinded, Randomized Controlled Trial
Sign Up to like & getrecommendations! Published in 2019 at "CNS Spectrums"
DOI: 10.1017/s1092852919000415
Abstract: Abstract Background Major depressive disorder (MDD) is a leading cause of disease burden worldwide, with lifetime prevalence in the United States of 17%. Here we present the results of the first prospective, large-scale, patient- and… read more here.
Keywords: care; response; arm; pgx ... See more keywords
Implementation of Pharmacogenomics- Where are we now?
Sign Up to like & getrecommendations! Published in 2022 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15591
Abstract: Pharmacogenomics (PGx), examining the effect of genetic variation on interpatient variation in drug disposition and response, has been widely studied for several decades. However, as cost, as well as turnaround time associated with PGx testing,… read more here.
Keywords: pharmacology; pgx testing; implementation pharmacogenomics; pgx ... See more keywords
Retrospective Review of Pharmacogenetic Testing at an Academic Children’s Hospital
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DOI: 10.1111/cts.12895
Abstract: There is limited evidence to support pharmacogenetic (PGx) testing in children. We conducted a retrospective review of PGx testing among 452 patients at an academic children’s hospital to determine the potential utility of PGx in… read more here.
Keywords: pgx; gene drug; drug; retrospective review ... See more keywords
Perceptions of pharmacogenetic exceptionalism and the implications for clinical management within an electronic health record
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13360
Abstract: Genetic exceptionalism refers to a concept that genetic information is distinct from other health data and therefore should have additional safety guards in place. The objective of this study was to establish perceptions of pharmacogenetic… read more here.
Keywords: health; exceptionalism; management; pgx ... See more keywords
The coming‐of‐age of pharmacogenetic testing in clinical psychiatry
Sign Up to like & getrecommendations! Published in 2019 at "Psychiatry and Clinical Neurosciences"
DOI: 10.1111/pcn.12832
Abstract: Pharmacogenetic (PGx) testing is key to addressing the issue of the prevailing ‘trial-and-error’ prescribing of medications in psychiatry. Expert groups have reported high evidence levels for several gene–drug pairs related to psychotropic medications with most… read more here.
Keywords: pgx; treatment; pgx testing; pgx tests ... See more keywords
Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/1758835920974118
Abstract: Background: Many cancer patients who receive chemotherapy experience adverse drug effects. Pharmacogenomics (PGx) has promise to personalize chemotherapy drug dosing to maximize efficacy and safety. Fluoropyrimidines and irinotecan have well-known germline PGx associations. At our… read more here.
Keywords: pgx; germline pgx; treatment; study ... See more keywords
Population structure and pharmacogenomic risk stratification in the United States
Sign Up to like & getrecommendations! Published in 2020 at "BMC Biology"
DOI: 10.1186/s12915-020-00875-4
Abstract: Background Pharmacogenomic (PGx) variants mediate how individuals respond to medication, and response differences among racial/ethnic groups have been attributed to patterns of PGx diversity. We hypothesized that genetic ancestry (GA) would provide higher resolution for… read more here.
Keywords: sire; risk stratification; population; pgx ... See more keywords
Improving cancer pain control: Potential impact of CYP2D6 pharmacogenomic (PGx) testing in oncology (Onc) patients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.12089
Abstract: 12089Background: Several opioid analgesics have well-known germline PGx associations which may predict either inefficacy or exaggerated (toxic) responses, depending on the patient’s genotype. Despi... read more here.
Keywords: improving cancer; pgx; cancer pain; pain control ... See more keywords