Recognizing hypoxia in phaeochromocytomas and paragangliomas
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DOI: 10.1038/s41574-020-0324-1
Abstract: Studies uncovering the cellular mechanisms of adaptation to varying oxygen levels were recognized with the 2019 Nobel Prize in Physiology or Medicine. Here, we focus on the remarkable parallels between the pathways regulating oxygen availability… read more here.
Keywords: medicine; phaeochromocytomas paragangliomas; endocrinology; physiology ... See more keywords
Examination of PHOX2B in adult neuroendocrine neoplasms reveals relatively frequent expression in phaeochromocytomas and paragangliomas
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DOI: 10.1111/his.13243
Abstract: Paired‐like homeobox 2b (PHOX2B) is a transcription factor with expression outside of the central nervous system restricted to neurons and chromaffin cells of the autonomic nervous system. Germline mutations cause congenital central hypoventilation syndrome and… read more here.
Keywords: phaeochromocytomas paragangliomas; nervous system; paragangliomas; expression ... See more keywords
Predictors of outcome in phaeochromocytomas and paragangliomas
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DOI: 10.12688/f1000research.12419.1
Abstract: Phaeochromocytomas and paragangliomas (PPGLs) are catecholamine-secreting neuroendocrine tumours characterised by high rates of heritability and genetic heterogeneity. Despite advances in the genetic diagnosis and improved understanding of the molecular aberrations underlying these tumours, predictive markers… read more here.
Keywords: predictors outcome; paragangliomas; outcome phaeochromocytomas; phaeochromocytomas paragangliomas ... See more keywords
Random 'spot' urinary metanephrines compared with 24-hour urinary and plasma results in phaeochromocytomas and paragangliomas.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of endocrinology"
DOI: 10.1530/eje-19-0809
Abstract: BACKGROUND In patients with phaeochromocytomas or paragangliomas (PPGLs), 24-hour urine collections for metanephrines (uMNs) are cumbersome. OBJECTIVE To evaluate the diagnostic utility of ratios to creatinine of 'spot' uMNs. METHODS Concentrations of uMNs and plasma… read more here.
Keywords: spot; phaeochromocytomas paragangliomas; hour urine; output ... See more keywords
Identification of Novel Mutations and Expressions of EPAS1 in Phaeochromocytomas and Paragangliomas
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DOI: 10.3390/genes11111254
Abstract: Endothelial PAS domain-containing protein 1 (EPAS1) is an oxygen-sensitive component of the hypoxia-inducible factors (HIFs) having reported implications in many cancers by inducing a pseudo-hypoxic microenvironment. However, the molecular dysregulation and clinical significance of EPAS1… read more here.
Keywords: epas1 mutations; phaeochromocytomas paragangliomas; novel mutations; paragangliomas ... See more keywords