Microenvironment Activated Nanozymes-Armed Bacteriophages Efficiently Combat Bacterial Infection.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202301349
Abstract: Bacterial infection is one of the greatest challenges to public health, requiring new therapeutic methods. Herein, an innovative nanozyme-armed phage (phage@Pd) system is fabricated for combating bacterial infection. The proposed phage@Pd preserves the function of… read more here.
Keywords: infection microenvironment; microenvironment activated; infection; phage ... See more keywords
Distinct Phage-Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202512937
Abstract: DNA base modification is a common strategy used by bacteriophages to evade host immune detection. A prominent example is dU‐DNA, where thymidine is globally replaced with 2′‐deoxyuridine. Despite its widespread occurrence, dU‐DNA's biosynthetic pathways and… read more here.
Keywords: enzymes substitution; phage; encoded enzymes; phage encoded ... See more keywords
Identification of a novel colon adenocarcinoma cell targeting peptide using phage display library biopanning
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2320
Abstract: Phage display is well recognized as a promising high‐throughput screening tool for the discovery of novel cancer‐targeting peptides. Here, we screened a phage display library of 7‐mer random peptides through in vitro biopanning to isolate… read more here.
Keywords: display library; cell; phage display; colon ... See more keywords
Phage‐resistant mutations impact bacteria susceptibility to future phage infections and antibiotic response
Sign Up to like & getrecommendations! Published in 2023 at "Ecology and Evolution"
DOI: 10.1002/ece3.9712
Abstract: Abstract Bacteriophage (phage) therapy in combination with antibiotic treatment serves as a potential strategy to overcome the continued rise in antibiotic resistance across bacterial pathogens. Understanding the impacts of evolutionary and ecological processes to the… read more here.
Keywords: antibiotic resistance; phage resistant; resistance; antibiotic response ... See more keywords
Albumin domain mutants with enhanced Aβ binding capacity identified by phage display analysis for application in various peripheral Aβ elimination approaches of Alzheimer's disease treatment
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2203
Abstract: Deposition of amyloid protein, particularly Aβ1‐42, is a major contributor to the onset of Alzheimer's disease (AD). However, almost no deposition of Aβ in the peripheral tissues could be found. Human serum albumin (HSA), the… read more here.
Keywords: binding capacity; phage display; alzheimer disease; phage ... See more keywords
Heteroaggregation of virions and microplastics reduces the number of active bacteriophages in aqueous environments.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of environmental quality"
DOI: 10.1002/jeq2.20459
Abstract: The objective of this study is to explore the effects of microplastics on the viability of the bacteriophages in an aqueous environment. Bacteriophages (phages), i.e., viruses of bacteria, are essential in homeostasis. It is estimated… read more here.
Keywords: heteroaggregation virions; virions microplastics; bacteriophages aqueous; number active ... See more keywords
Phenotypic characterization of phage vB_vcM_Kuja
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Basic Microbiology"
DOI: 10.1002/jobm.202200635
Abstract: Bacteriophage therapy targeting the increasingly resistant Vibrio cholerae is highly needed. Hence, studying the phenotypic behavior of potential phages under different conditions is a prerequisite to delivering the phage in an active infective form. The… read more here.
Keywords: phenotypic characterization; vcm kuja; phage;
Genetically distant bacteriophages select for unique genomic changes in Enterococcus faecalis
Sign Up to like & getrecommendations! Published in 2022 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.1273
Abstract: The human microbiota harbors diverse bacterial and bacteriophage (phage) communities. Bacteria evolve to overcome phage infection, thereby driving phage evolution to counter bacterial resistance. Understanding how phages select for genetic alterations in medically relevant bacteria… read more here.
Keywords: genetically distant; infection; faecalis genome; phage infection ... See more keywords
Bacteriocin‐phage interaction (BaPI): Phage predation of Lactococcus in the presence of bacteriocins
Sign Up to like & getrecommendations! Published in 2022 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.1308
Abstract: Bacteriophages infecting dairy starter bacteria are a leading cause of milk fermentation failure and strategies to reduce the risk of phage infection in dairy settings are demanded. Along with dairy starters, bacteriocin producers (protective cultures)… read more here.
Keywords: presence; phage predation; bapi; bacteriocin phage ... See more keywords
Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6869-5_14
Abstract: The generation of a strong antibody response to target antigens is a major goal for vaccine development. Here we describe the display of the human immunodeficiency virus (HIV) envelope spike protein (Env) on a virus-like… read more here.
Keywords: phage; hiv envelope; display; vaccine platform ... See more keywords
Preparing cDNA Libraries from Lytic Phage-Infected Cells for Whole Transcriptome Analysis by RNA-Seq.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7343-9_14
Abstract: Whole genome wide analysis of transcription using RNA-Seq methods is a powerful way to elucidate differential expression of gene features in bacteria across different conditions as well as for discovering previously exotic RNA species. Indeed,… read more here.
Keywords: analysis; phage; rna; rna seq ... See more keywords