Survey on the phage resistance mechanisms displayed by a dairy Lactobacillus helveticus strain.
Sign Up to like & getrecommendations! Published in 2017 at "Food microbiology"
DOI: 10.1016/j.fm.2017.04.014
Abstract: In this study the presence and functionality of phage defence mechanisms in Lactobacillus helveticus ATCC 10386, a strain of dairy origin which is sensitive to ΦLh56, were investigated. After exposure of ATCC 10386 to ΦLh56,… read more here.
Keywords: phage; atcc 10386; lactobacillus helveticus; resistance ... See more keywords
Phage-bacterial evolutionary interactions: experimental models and complications.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in microbiology"
DOI: 10.1080/1040841x.2022.2052793
Abstract: Phage treatment of bacterial infections has offered some hope even as the crisis of antimicrobial resistance continues to be on the rise. However, bacterial resistance to phage is another looming challenge capable of undermining the… read more here.
Keywords: bacterial evolutionary; phage bacterial; evolutionary interactions; resistance ... See more keywords
Network approach to mutagenesis sheds insight on phage resistance in mycobacteria
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaa1103
Abstract: MOTIVATION A rigorous yet general mathematical approach to mutagenesis, especially one capable of delivering systems-level perspectives would be invaluable. Such systems-level understanding of phage resistance is also highly desirable for phage-bacteria interactions and phage therapy… read more here.
Keywords: network; phage; approach mutagenesis; shortest paths ... See more keywords
A lipopolysaccharide‐dependent phage infects a pseudomonad phytopathogen and can evolve to evade phage resistance
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Microbiology"
DOI: 10.1101/2022.06.10.495718
Abstract: Bacterial pathogens are major causes of crop diseases, leading to significant production losses. For instance, kiwifruit canker, caused by the phytopathogen Pseudomonas syringae pv. actinidiae (Psa), has posed a global challenge to kiwifruit production. Treatment… read more here.
Keywords: phage resistance; dependent phage; lipopolysaccharide dependent; phytopathogen ... See more keywords
Bacteriophage Resistance Affects Flavobacterium columnare Virulence Partly via Mutations in Genes Related to Gliding Motility and the Type IX Secretion System
Sign Up to like & getrecommendations! Published in 2021 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.00812-21
Abstract: Phage resistance of infectious bacteria is a common phenomenon posing challenges for the development of phage therapy. Along with a growing world population and the need for increased food production, constantly intensifying animal farming has… read more here.
Keywords: resistance; columnare; phage therapy; phage ... See more keywords
Selection for Phage Resistance Reduces Virulence of Shigella flexneri
Sign Up to like & getrecommendations! Published in 2021 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01514-21
Abstract: Shigella flexneri is a facultative intracellular pathogen of humans and a leading cause of bacillary dysentery. With few effective treatments and rising antibiotic resistance in these bacteria, there is increasing interest in alternatives to classical… read more here.
Keywords: shigella flexneri; flexneri; phage; virulence ... See more keywords
Phage Resistance Accompanies Reduced Fitness of Uropathogenic Escherichia coli in the Urinary Environment
Sign Up to like & getrecommendations! Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00345-22
Abstract: UTI is one of the most common causes of outpatient antibiotic use, and rising antibiotic resistance threatens the ability to control UTI unless alternative treatments are developed. Bacteriophage (phage) therapy is gaining renewed interest; however,… read more here.
Keywords: phage resistance; phage therapy; urinary environment; resistance ... See more keywords
Hypoxia Increases the Tempo of Phage Resistance and Mutational Bottlenecking of Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.905343
Abstract: Viruses that infect bacteria (i.e., phages) are abundant and widespread in the human body, and new anti-infective approaches such as phage therapy are essential for the future of effective medicine. Our understanding of microenvironmental factors… read more here.
Keywords: phage resistance; pseudomonas aeruginosa; hypoxia; hypoxia increases ... See more keywords
Understanding the Mechanisms That Drive Phage Resistance in Staphylococci to Prevent Phage Therapy Failure
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14051061
Abstract: Despite occurring at the microscopic scale, the armed race between phages and their bacterial hosts involves multiple mechanisms, some of which are just starting to be understood. On the one hand, bacteria have evolved strategies… read more here.
Keywords: phage resistance; phage therapy; failure; resistance ... See more keywords
Competition between lysogenic and sensitive bacteria is determined by the fitness costs of the different emerging phage-resistance strategies
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.83479
Abstract: Many bacterial genomes carry prophages whose induction can eliminate competitors. In response, bacteria may become resistant by modifying surface receptors, by lysogenization, or by other poorly known processes. All these mechanisms affect bacterial fitness and… read more here.
Keywords: phage resistance; resistance phages; resistance; lysogenic sensitive ... See more keywords