How the phagocyte NADPH oxidase regulates innate immunity
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.06.011
Abstract: ABSTRACT The phagocyte NADPH oxidase is a multi subunit protein complex that generates reactive oxygen species at cell membranes and within phagosomes. It is essential for host defence as evidenced by the severe immunodeficiency syndrome… read more here.
Keywords: nadph oxidase; oxidase; phagocyte nadph; innate immunity ... See more keywords
Arginine Metabolism Powers Salmonella Resistance to Oxidative Stress
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00120-23
Abstract: Salmonella invades host cells and replicates inside acidified, remodeled vacuoles that are exposed to reactive oxygen species (ROS) generated by the innate immune response. Oxidative products of the phagocyte NADPH oxidase mediate antimicrobial activity, in… read more here.
Keywords: stress; arginine; salmonella; phagocyte nadph ... See more keywords
EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.76387
Abstract: EROS (Essential for Reactive Oxygen Species) protein is indispensable for expression of gp91phox, the catalytic core of the phagocyte NADPH oxidase. EROS deficiency in humans is a novel cause of the severe immunodeficiency, chronic granulomatous… read more here.
Keywords: eros selective; selective chaperone; phagocyte nadph; nadph oxidase ... See more keywords