Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD
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DOI: 10.1038/s42003-025-08368-2
Abstract: Genetic mutations in the progranulin gene, GRN, cause frontotemporal dementia and a lysosomal storage disorder. Using single-nuclei RNA sequencing of the post-mortem brain tissue from adult heterozygous pathogenic granulin variant (GRN+/−) carriers we find dysregulation… read more here.
Keywords: mertk axl; phagocytic receptors; ftd; grn ... See more keywords