The Microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid‐β by microglia
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14336
Abstract: Considerable evidence links the microglial transmembrane receptor TREM2 to the progression of Alzheimer's disease through its involvement in Aβ phagocytosis by microglia. While previous studies have mainly focused on the phagocytic regulation of microglia itself,… read more here.
Keywords: exosome secretion; phagocytosis; receptor trem2;
Macrophage-Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced functional materials"
DOI: 10.1002/adfm.202006220
Abstract: Macrophages are one of the most abundant non-malignant cells in the tumor microenvironment, playing critical roles in mediating tumor immunity. As important innate immune cells, macrophages possess the potential to engulf tumor cells and present… read more here.
Keywords: intervention; macrophage phagocytosis; phagocytosis; tumor cells ... See more keywords
Engineered Bacterial Outer Membrane Vesicles as Controllable Two‐Way Adaptors to Activate Macrophage Phagocytosis for Improved Tumor Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202206200
Abstract: The most immune cells infiltrating tumor microenvironment (TME), tumor‐associated macrophages (TAMs) closely resemble immunosuppressive M2‐polarized macrophages. Moreover, tumor cells exhibit high expression of CD47 “don't eat me” signal, which obstructs macrophage phagocytosis. The precise and… read more here.
Keywords: two way; phagocytosis; cd47nb; omv cd47nb ... See more keywords
Bone Marrow Mesenchymal Stem Cell-Derived Dermcidin-Containing Migrasomes enhance LC3-Associated Phagocytosis of Pulmonary Macrophages and Protect against Post-Stroke Pneumonia.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206432
Abstract: Pneumonia is one of the leading causes of death in patients with acute ischemic stroke (AIS). Antibiotics fail to improve prognosis of patients with post-stroke pneumonia, albeit suppressing infection, due to adverse impacts on the… read more here.
Keywords: bone marrow; post stroke; phagocytosis; stroke pneumonia ... See more keywords
Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid‐β Plaques
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202503389
Abstract: In Alzheimer's disease (AD), microglia are activated by mechanical and biochemical cues in the amyloid‐β (Aβ) plaque‐associated microenvironment, causing neuroinflammation. While the impact of Aβ stiffness on microglial activation and the dynamic interplay between inflammation… read more here.
Keywords: mechanotransduction activates; microglial activation; phagocytosis; microglia impairs ... See more keywords
Protein S Enhances the Phagocytosis of Phosphatidylserine‐Exposing Erythrocytes: Implications in Sickle Cell Disease
Sign Up to like & getrecommendations! Published in 2025 at "American Journal of Hematology"
DOI: 10.1002/ajh.70117
Abstract: The major anticoagulant Protein S (PROS1) also contributes to the phagocytosis of apoptotic cells by bridging exposed phosphatidylserine (PtdSer) to the MerTK receptor on macrophages (efferocytosis). Whether PROS1 is involved in the splenic clearance of… read more here.
Keywords: enhances phagocytosis; cell disease; phagocytosis; pros1 ... See more keywords
Detection of LC3‐Associated Phagocytosis (LAP)
Sign Up to like & getrecommendations! Published in 2020 at "Current Protocols in Cell Biology"
DOI: 10.1002/cpcb.104
Abstract: Phagocytes, notably macrophages, are critical sentinels of their environment, patrolling for and eradicating unwanted components. The ability of cells to process extracellular cargo in an appropriate manner is important for both clearance of the cargo… read more here.
Keywords: associated phagocytosis; phagocytosis lap; lc3 associated; phagocytosis ... See more keywords
Quantifying Microglial Phagocytosis of Apoptotic Cells in the Brain in Health and Disease
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DOI: 10.1002/cpim.49
Abstract: Apoptosis is a ubiquitous process occurring in the brain under both physiological and pathological conditions. The central nervous system (CNS) requires an active and efficient clean‐up system to prevent the spillover of intracellular contents into… read more here.
Keywords: phagocytosis apoptotic; phagocytosis; apoptotic cells; microglial phagocytosis ... See more keywords
Synaptotagmin‐11 inhibits cytokine secretion and phagocytosis in microglia
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23186
Abstract: Cytokine secretion and phagocytosis are key functions of activated microglia. However, the molecular mechanisms underlying their regulation in microglia remain largely unknown. Here, we report that synaptotagmin‐11 (Syt11), a non‐Ca2+‐binding Syt implicated in Parkinson disease… read more here.
Keywords: secretion; microglia; phagocytosis; cytokine secretion ... See more keywords
Phagocytic astrocytes: Emerging from the shadows of microglia
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DOI: 10.1002/glia.24145
Abstract: Elimination of dead or live cells take place in both a healthy and diseased central nervous system (CNS). Dying or dead cells are quickly cleared by phagocytosis for the maintenance of a healthy CNS or… read more here.
Keywords: shadows microglia; phagocytosis; astrocytes emerging; phagocytic astrocytes ... See more keywords
Alzheimer's disease‐associated R47H TREM2 increases, but wild‐type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss
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DOI: 10.1002/glia.24318
Abstract: Triggering receptor on myeloid cells 2 (TREM2) is an innate immune receptor, upregulated on the surface of microglia associated with amyloid plaques in Alzheimer's disease (AD). Individuals heterozygous for the R47H variant of TREM2 have… read more here.
Keywords: r47h trem2; trem2; phagocytosis; neuronal loss ... See more keywords