Targeting macrophage-mediated tumor cell phagocytosis: An overview of phagocytosis checkpoints blockade, nanomedicine intervention, and engineered CAR-macrophage therapy.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108499
Abstract: Immunotherapy has been developing at an unprecedented speed with promising therapeutic outcomes in the wide spectrum of cancers. Up until now, most immunotherapies have focused on adaptive immunity; however, investigating the potential of macrophage phagocytosis… read more here.
Keywords: targeting macrophage; phagocytosis checkpoints; macrophage; car macrophage ... See more keywords
Phagocytosis checkpoints as new targets for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Cancer"
DOI: 10.1038/s41568-019-0183-z
Abstract: Cancer immunotherapies targeting adaptive immune checkpoints have substantially improved patient outcomes across multiple metastatic and treatment-refractory cancer types. However, emerging studies have demonstrated that innate immune checkpoints, which interfere with the detection and clearance of… read more here.
Keywords: phagocytosis; phagocytosis checkpoints; cancer immunotherapy; cancer ... See more keywords