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Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.02.015
Abstract: Phagolysosome membrane rupture can trigger a maladaptive immune response that promotes tissue damage. In Science, Cantuti-Castelvetri et al. (2018) report that cholesterol-rich myelin debris overwhelms reverse cholesterol transport in aged phagocytes, leading to cholesterol crystal formation,…
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Keywords:
phagolysosomal damage;
cholesterol;
damage;
heart phagolysosomal ... See more keywords