C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodeling
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.137029
Abstract: Critical illness is accompanied by the release of large amounts of the anaphylotoxin, C5a. C5a suppresses antimicrobial functions of neutrophils which is associated with adverse outcomes. The signaling pathways that mediate C5a-induced neutrophil dysfunction are… read more here.
Keywords: phagosomal maturation; c5a impairs; phagosomal acidification; impairs phagosomal ... See more keywords
Tirap controls Mycobacterium tuberculosis phagosomal acidification
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DOI: 10.1371/journal.ppat.1011192
Abstract: Progression of tuberculosis is tightly linked to a disordered immune balance, resulting in inability of the host to restrict intracellular bacterial replication and its subsequent dissemination. The immune response is mainly characterized by an orchestrated… read more here.
Keywords: mycobacterium tuberculosis; tuberculosis; tirap; mtb infection ... See more keywords