CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Cell"
DOI: 10.1016/j.devcel.2017.11.024
Abstract: Summary Mechanisms of selective autophagy of the ER, known as ER-phagy, require molecular delineation, particularly in vivo. It is unclear how these events control ER proteostasis and cellular health. Here, we identify cell-cycle progression gene… read more here.
Keywords: protein; cargo receptor; ccpg1; non canonical ... See more keywords
ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reviews"
DOI: 10.1152/physrev.00038.2021
Abstract: ER-phagy (reticulo-phagy) defines the degradation of portions of the endoplasmic reticulum (ER) within lysosomes or vacuoles. It is part of the self-digestion (i.e., auto-phagic) programs recycling cytoplasmic material and organelles, which rapidly mobilize metabolites in… read more here.
Keywords: clearance; endoplasmic reticulum; phagy mechanisms; lysosomes vacuoles ... See more keywords
2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-2926
Abstract: Tumor metabolism is reprogrammed to meet the demands of proliferating cancer cells. In particular, cancer cells upregulate synthesis of the membrane phospholipids phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdE) in order to allow for rapid membrane turnover.… read more here.
Keywords: biosynthesis; gliomas; phospholipid biosynthesis; idh1 ... See more keywords
ROOT HAIR DEFECTIVE3 Is a Receptor for Selective Autophagy of the Endoplasmic Reticulum in Arabidopsis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.817251
Abstract: ROOT HAIR DEFECTIVE3 (RHD3) is a plant member of atlastin GTPases, which belong to an evolutionally conserved family of proteins that mediate the homotypic fusion of the endoplasmic reticulum (ER). An atlastin in mammalian cells… read more here.
Keywords: rhd3; root hair; selective autophagy; phagy ... See more keywords
ER-phagy in the Occurrence and Development of Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10030707
Abstract: As an organelle, the endoplasmic reticulum (ER) is closely related to protein synthesis and modification. When physiological or pathological stimuli induce disorders of ER function, misfolded proteins trigger ER-phagy, which is beneficial for restoring cell… read more here.
Keywords: occurrence; cell; development; phagy ... See more keywords
FAM134B-mediated ER-phagy alleviates endoplasmic reticulum stress of rat soleus muscle in response to acute exercise.
Sign Up to like & getrecommendations! Published in 2022 at "General physiology and biophysics"
DOI: 10.4149/gpb_2021046
Abstract: ER-phagy is a selective endoplasmic reticulum (ER) autophagy mediated by ER-localized receptors, which ensures proper cellular homeostasis under stress. However, it remains unclear whether ER-phagy is involved in skeletal muscle response to exercise stress. Male… read more here.
Keywords: endoplasmic reticulum; stress; muscle; phagy ... See more keywords