Preparation of pharmaceutical cocrystal formulations via melt mixing technique: A thermodynamic perspective
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.08.002
Abstract: Graphical abstract Figure. No caption available. ABSTRACT The aim of the present study was to evaluate the thermodynamic properties of in‐situ formation of cocrystal formulations by the melt‐mixing method. Specifically, the thermodynamic mixing behaviour of… read more here.
Keywords: via melt; formulations via; cocrystal formulations; melt mixing ... See more keywords
Novel pharmaceutical cocrystal of lenalidomide with nicotinamide: Structural design, evaluation, and thermal phase transition study.
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DOI: 10.1016/j.ijpharm.2021.121394
Abstract: Lenalidomide (LDM), widely used for the treatment of transfusion-dependent anaemia, has low oral bioavailability due to its poor aqueous solubility. Herein, we selected nicotinamide (NIC) as a coformer and synthesized a novel pharmaceutical cocrystal: lenalidomide-nicotinamide… read more here.
Keywords: pharmaceutical cocrystal; novel pharmaceutical; phase transition; cocrystal lenalidomide ... See more keywords
Pharmaceutical Cocrystal Drug Products: An Outlook on Product Development.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2018.10.006
Abstract: Active pharmaceutical ingredients (APIs) are most commonly formulated and delivered to patients in the solid state. Recently, an alternative API solid-state form, namely the pharmaceutical cocrystal, has witnessed increasing academic and industrial interest due to… read more here.
Keywords: cocrystal drug; drug products; product; drug ... See more keywords
Binary polymorphic cocrystals: an update on the available literature in the Cambridge Structural Database, including a new polymorph of the pharmaceutical 1:1 cocrystal theophylline-3,4-dihydroxybenzoic acid.
Sign Up to like & getrecommendations! Published in 2018 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229618006861
Abstract: An analysis and classification of the 2925 neutral binary organic cocrystals in the Cambridge Structural Database is reported, focusing specifically on those both showing polymorphism and containing an active pharmaceutical ingredient (API). The search was… read more here.
Keywords: structural database; new polymorph; polymorph pharmaceutical; cambridge structural ... See more keywords
Pharmaceutical Cocrystal: An Antique and Multifaceted Approach.
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DOI: 10.2174/1567201813666161018152411
Abstract: BACKGROUND Pharmaceutical cocrystal is an emerging approach to tailor physicochemical and mechanical properties of drug substances. Cocrystals are composed of API and pharmaceutically acceptable coformer. It is used to address the solubility, dissolution, mechanical properties… read more here.
Keywords: drug substances; drug; mechanical properties; cocrystal antique ... See more keywords
SOLID-STATE PROPERTIES AND SOLUBILITY STUDIES OF NOVEL PHARMACEUTICAL COCRYSTAL OF ITRACONAZOLE
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2018v10i5.26663
Abstract: Objective: Pharmaceutical cocrystal is a promising method to improve the solubility of active pharmaceutical ingredients (APIs). Itraconazole (ITZ) is a BCS class II antifungal drug with poor aqueous solubility, therefore an attempt was made to… read more here.
Keywords: novel pharmaceutical; solubility itz; itz; solubility ... See more keywords