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   Articles with "pharmaceutical cocrystals" as a keyword



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Preface: Engineering of pharmaceutical cocrystals, salts and polymorphs: Advances and Challenges.

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recommendations! Published in 2017 at "Advanced drug delivery reviews"

DOI: 10.1016/j.addr.2017.10.002

Abstract: Since the middle of 19 century, it is known that pharmaceutical substances can exist in more than one stable crystalline, or an unstable amorphous form. The screening, identification and characterization of the solid forms of… read more here.

Keywords: salts polymorphs; engineering; engineering pharmaceutical; drug ... See more keywords
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Diffusion and Flux Improvement of Drugs through Complexation.

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recommendations! Published in 2023 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.3c00159

Abstract: Improving the solubility and permeability of drugs via cocrystallization is an important theme in crystal engineering with practical applications for the discovery and development of high bioavailability medicines. The past decade has witnessed a surge… read more here.

Keywords: diffusion; flux; cocrystals salts; pharmaceutical cocrystals ... See more keywords
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Pharmaceutical cocrystals of naringenin with improved dissolution performance

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recommendations! Published in 2018 at "CrystEngComm"

DOI: 10.1039/c8ce00341f

Abstract: Naringenin (NAR), a natural flavanone compound, has received increasing attention in recent years due to its diverse pharmacological activities. However, this bioflavonoid shows poor solubility and therefore is difficult to absorb on oral ingestion. To… read more here.

Keywords: dissolution performance; naringenin improved; improved dissolution; cocrystals naringenin ... See more keywords
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Evaluation of synthon influence on ethenzamide-polyphenol pharmaceutical cocrystals

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recommendations! Published in 2023 at "CrystEngComm"

DOI: 10.1039/d3ce00234a

Abstract: Pharmaceutical cocrystal landscape of ethenzamide has been addressed during the past years with the aim of improving its physicochemical properties, mainly solubility and dissolution rate. Herein four novel ethenzamide cocrystals... read more here.

Keywords: polyphenol pharmaceutical; influence ethenzamide; synthon influence; evaluation synthon ... See more keywords
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Comparison of the relative stability of pharmaceutical cocrystals consisting of paracetamol and dicarboxylic acids

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recommendations! Published in 2018 at "Drug Development and Industrial Pharmacy"

DOI: 10.1080/03639045.2017.1405433

Abstract: Abstract Objective: The aim of this study is to evaluate the relative stability of pharmaceutical cocrystals consisting of paracetamol (APAP) and oxalic acid (OXA) or maleic acid (MLA). Significance: These observations of cocrystal stability under… read more here.

Keywords: consisting paracetamol; cocrystals consisting; stability pharmaceutical; relative stability ... See more keywords
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Crystal structure of pharmaceutical cocrystals of 2,6-diaminopyridine with piracetam and theophylline.

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recommendations! Published in 2017 at "Acta crystallographica. Section C, Structural chemistry"

DOI: 10.1107/s205322961701230x

Abstract: Pharmaceutical cocrystals are crystalline solids formed by an active pharmaceutical ingredient and a cocrystal former. The cocrystals 2,6-diaminopyridine (DAP)-piracetam [PIR; systematic name: 2-(2-oxopyrrolidin-1-yl)acetamide] (1/1), C5H7N3·C6H10N2O2, (I), and 2,6-diaminopyridine-theophylline (TEO; systematic name: 1,3-dimethyl-7H-purine-2,6-dione) (1/1), C5H7N3·C7H8N4O2, (II),… read more here.

Keywords: crystal structure; pharmaceutical cocrystals; piracetam theophylline; diaminopyridine piracetam ... See more keywords

Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals

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recommendations! Published in 2023 at "Pharmaceuticals"

DOI: 10.3390/ph16030370

Abstract: Pharmaceutical multicomponent solids have proved to efficiently modulate the physicochemical properties of active pharmaceutical ingredients. In this context, polyphenols are interesting coformers for designing pharmaceutical cocrystals due to their wide safety profile and interesting antioxidant… read more here.

Keywords: rational coformer; propyl thiouracil; coformer selection; thiouracil ... See more keywords