Feasible TLC-Spectro-Densitometry Technique for Simultaneous Determination of Two Hepatitis C Antiviral Drugs, Sofosbuvir and Simeprevir: Application to Combined Pharmaceutical Dosage Forms and Human Plasma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmab034
Abstract: A high-performance thin-layer chromatographic method was developed and validated for the concurrent determination of simeprevir (SMV) and sofosbuvir (SOF). The chromatographic separation was attained on silica gel 60 F254 as stationary phase and ethyl acetate-hexane-methanol… read more here.
Keywords: pharmaceutical dosage; determination; human plasma; sof ... See more keywords
Validated Smart Different Chromatographic Methods for Selective Quantification of Acefylline Piperazine, Phenobarbital Sodium and Methylparaben Additive in Bulk and Pharmaceutical Dosage Form.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmac003
Abstract: Two chromatographic methods have been proposed for the simultaneous determination of acefylline piperazine (ACEF) and phenobarbital (PHENO) in presence of methylparaben as additive in pharmaceutical dosage form. The first method was thin-layer chromatography. The separation… read more here.
Keywords: phase; dosage form; pharmaceutical dosage; chromatographic methods ... See more keywords
Development, Robustness by Design Expert and Validation of a Method for Enantiomeric Impurity Content Determination in Pretomanid Drug Substance and Pharmaceutical Dosage Form.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmac090
Abstract: For the purpose of identifying enantiomeric impurities in the drug substance and pharmaceutical dosage forms of the novel anti-TB medication pretomanid, an RP-high-performance liquid chromatography method was devised. To ensure the robustness of the optimized… read more here.
Keywords: substance pharmaceutical; pharmaceutical dosage; drug substance; robustness ... See more keywords
Photostability Issues in Pharmaceutical Dosage Forms and Photostabilization
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DOI: 10.1208/s12249-017-0869-z
Abstract: Photodegradation is one of the major pathways of the degradation of drugs. Some therapeutic agents and excipients are highly sensitive to light and undergo significant degradation, challenging the quality and the stability of the final… read more here.
Keywords: photostability; pharmaceutical dosage; photodegradation; photostability issues ... See more keywords
Application of design space and quality by design methodologies combined with ultra high-performance liquid chromatography for the optimization of the sample preparation of complex pharmaceutical dosage forms.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.2139/ssrn.4033071
Abstract: Accurate and precise analytical measurements play a significant role in assessments and decisions that are made throughout the drug development process. Developing a robust and reliable sample preparation is essential for drug product formulations to… read more here.
Keywords: sample preparation; preparation; pharmaceutical dosage; design ... See more keywords
Development and validation of an HPLC method for five gliptins in pharmaceutical dosage forms in finished marketed products
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DOI: 10.2174/1573412917999201102212635
Abstract: Metformin is the most used antihyperglycemic drug in diabetes, and therefore it is preferred to be combined with other classes of antihyperglycemic drugs, specially gliptins. Formulating of these two classes of drug in one pharmaceutical… read more here.
Keywords: pharmaceutical dosage; development validation; method; drug ... See more keywords
Rapid Capillary Electrophoresis Method for Simultaneous Determination of Abemaciclib, Ribociclib, and Palbociclib in Pharmaceutical Dosage Forms: A Green Approach
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DOI: 10.3390/molecules27217603
Abstract: Advances in the treatment of HR+/HER2- breast cancer phenotype have been made with the introduction of abemaciclib, ribociclib, and palbociclib, inhibitors of cyclin D dependent kinases 4 and 6 (CDK4/6). Here, a novel, fast, cheap,… read more here.
Keywords: method simultaneous; ribociclib palbociclib; abemaciclib ribociclib; pharmaceutical dosage ... See more keywords
Image Analysis: A Versatile Tool in the Manufacturing and Quality Control of Pharmaceutical Dosage Forms
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DOI: 10.3390/pharmaceutics13050685
Abstract: In pharmaceutical sciences, visual inspection is one of the oldest methods used for description in pharmacopeias and is still an important part of the characterization and qualification of active ingredients, excipients, and dosage forms. With… read more here.
Keywords: pharmaceutical dosage; manufacturing quality; dosage forms; dosage ... See more keywords
Development of a Standardized Method for Measuring Bioadhesion and Mucoadhesion That Is Applicable to Various Pharmaceutical Dosage Forms
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DOI: 10.3390/pharmaceutics14101995
Abstract: Although some methods for measuring bioadhesion/mucoadhesion have been proposed, a standardized method is not yet available. This is expected to hinder systematic comparisons of results across studies. This study aimed to design a single/systematic in… read more here.
Keywords: measuring bioadhesion; pharmaceutical dosage; bioadhesion mucoadhesion; method ... See more keywords
Quantitative bioanalytical and analytical methods for estimation of ivabradine hydrochloride in pure and pharmaceutical dosage form
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Reports in Pharmaceutical Sciences"
DOI: 10.4103/jrptps.jrptps_110_19
Abstract: Introduction: New analytical and bioanalytical methods were developed for the estimation of Ivabradine hydrochloride in bulk and pharmaceutical dosage form by UV spectrophotometry and high-performance liquid chromatography (HPLC) technique. Objective: The primary objective of the… read more here.
Keywords: pharmaceutical dosage; ivabradine hydrochloride; method; ivabradine ... See more keywords
Electroanalytical Determination of the Antiinflammatory Drug Tenoxicam in Pharmaceutical Dosage Forms
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DOI: 10.4274/tjps.galenos.2018.60783
Abstract: Objectives: The electro-oxidation behavior of the non-steroidal anti-inflammatory drug tenoxicam (TX) was studied on multiwalled carbon nanotube (MWCNT)-modified glassy carbon electrode (GCE) by cyclic voltammetry, differential pulse voltammetry (DPV), and square wave voltammetry (SWV). Materials… read more here.
Keywords: determination; pharmaceutical dosage; drug tenoxicam; dpv ... See more keywords