Interaction Between an Active Pharmaceutical Ingredient Ionic Liquid Benzalkonium Salicylate and Small Biomolecules in Aqueous Solution: UV Absorption, Conductivity, and Volumetric Study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Solution Chemistry"
DOI: 10.1007/s10953-018-0810-4
Abstract: UV absorption spectroscopy, electrical conductivity and density experiments have been used to investigate the interactions of some small biomolecules (amino acids/dipeptides) with an active pharmaceutical ingredient in ionic liquid form (API-IL), benzalkonium salicylate (BaSal), in… read more here.
Keywords: ingredient ionic; small biomolecules; active pharmaceutical; pharmaceutical ingredient ... See more keywords
Tailoring the crystal size distribution of an active pharmaceutical ingredient by continuous antisolvent crystallization in a planar oscillatory flow crystallizer
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Engineering Research and Design"
DOI: 10.1016/j.cherd.2021.08.030
Abstract: Abstract An active pharmaceutical ingredient is currently produced in a traditional batch antisolvent crystallization process. Although well-established, this process lacks flexibility to control the crystal size distribution (CSD). Therefore, a new process was developed to… read more here.
Keywords: planar; antisolvent crystallization; crystal size; pharmaceutical ingredient ... See more keywords
Polymorphism of benzylthiouracil, an active pharmaceutical ingredient against hyperthyroidism.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120378
Abstract: The crystal structures of dimorphic benzylthiouracil, a drug against hyperthyroidism, have been redetermined and the atom coordinates of the two independent molecules of form I have been obtained for the first time. The dimorphism convincingly… read more here.
Keywords: hyperthyroidism; ingredient hyperthyroidism; benzylthiouracil active; active pharmaceutical ... See more keywords
Studies on the interactions of some small biomolecules with antibacterial drug benzethonium chloride and its active pharmaceutical ingredient ionic liquid (API-IL) benzethonium L-proline at varying temperatures
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2018.02.007
Abstract: Abstract From the conductivity, density and spectroscopy measurements, the interactions of benzethonium chloride ([BTC]) and its active pharmaceutical ingredient in ionic liquid format benzethonium L-proline ([BT][PRO]) with some amino acids and glycyl dipeptides have been… read more here.
Keywords: ingredient ionic; small biomolecules; active pharmaceutical; pharmaceutical ingredient ... See more keywords
Conformational Preference and Spectroscopical Characteristics of the Active Pharmaceutical Ingredient Levetiracetam.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.08.008
Abstract: The analysis of the possible conformers and the conformational change between solid and liquid states of a particular drug molecule are mandatory not only for describing reliably its spectroscopical properties but also for understanding the… read more here.
Keywords: spectroscopical characteristics; conformational preference; characteristics active; active pharmaceutical ... See more keywords
Identification of an adduct impurity of an active pharmaceutical ingredient and a leachable in an ophthalmic drug product using LC-QTOF.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.06.009
Abstract: Impurity investigations are important in pharmaceutical development to ensure drug purity and safety for the patient. The impurities typically found in drug products are degradants or reaction products of the active pharmaceutical ingredient (API), or… read more here.
Keywords: adduct; mass; active pharmaceutical; pharmaceutical ingredient ... See more keywords
Active pharmaceutical ingredient (API) chemicals: a critical review of current biotechnological approaches
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DOI: 10.1080/21655979.2022.2031412
Abstract: ABSTRACT The aim of this article was to generate a framework of bio-based economy by an effective utilization of biomass from the perspectives of agriculture for developing potential end bio-based products (e.g. pharmaceuticals, active pharmaceutical… read more here.
Keywords: api chemicals; ingredient api; bio based; biotechnological approaches ... See more keywords
Crystal structure of pirfenidone (5-methyl-1-phenyl-1H-pyridin-2-one): an active pharmaceutical ingredient (API)
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DOI: 10.1107/s2056989019006418
Abstract: The crystal structure of pirfenidone, [5-methyl-1-phenylpyridin-2(1H)-one], an active pharmaceutical ingredient (API) approved in Europe and Japan for the treatment of idiopathic pulmonary fibrosis (IPF), is reported here for the first time. It was crystallized from… read more here.
Keywords: active pharmaceutical; structure pirfenidone; pirfenidone methyl; one active ... See more keywords
Transmission Raman Spectroscopic Quantification of Active Pharmaceutical Ingredient in Coated Tablets of Hot-Melt Extruded Amorphous Solid Dispersion
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DOI: 10.1177/0003702819884994
Abstract: Transmission Raman spectroscopy is an emerging technique, capable of quantitative analysis of drug products nondestructively using a multivariate data analysis approach. We developed and validated a chemometric method to quantify the active pharmaceutical ingredient in… read more here.
Keywords: active pharmaceutical; transmission raman; pharmaceutical ingredient; spectroscopy ... See more keywords
CO-CRYSTALS OF ACTIVE PHARMACEUTICAL INGREDIENT-IBUPROFEN LYSINE
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DOI: 10.22159/ijap.2020v12i3.36463
Abstract: Objective: Co-crystal is defined as a crystalline complex of two or more neutral molecules bound together primarily by hydrogen bonding or other non-covalent interactions. The pharmaceutical co-crystal involves crystal lattice arrangement between an Active Pharmaceutical… read more here.
Keywords: ibuprofen; pharmaceutical ingredient; active pharmaceutical; solubility ... See more keywords
Development and Validation of a Method for the Semi-Quantitative Determination of N-Nitrosamines in Active Pharmaceutical Ingredient Enalapril Maleate by Means of Derivatisation and Detection by HPLC with Fluorimetric Detector
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DOI: 10.3390/app11167590
Abstract: A novel HPLC method with fluorimetric detection was developed for the determination of potentially carcinogenic N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) in active pharmaceutical ingredient enalapril maleate. N-nitrosamines were subject to denitrosation followed by derivatisation with… read more here.
Keywords: hplc; enalapril maleate; active pharmaceutical; pharmaceutical ingredient ... See more keywords