THU0173 FILGOTINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS AND PRIOR INADEQUATE RESPONSE OR INTOLERANCE TO BIOLOGICAL DMARDS (BDMARD-IR) BY RACE & GEOGRAPHIC REGION
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DOI: 10.1136/annrheumdis-2019-eular.2323
Abstract: Background Filgotinib (FIL), an oral, selective Janus kinase 1 (JAK1) inhibitor, significantly improved the signs and symptoms of rheumatoid arthritis (RA) in the phase 3 FINCH2 study in bDMARD-IR patients with active RA.1 Objectives To… read more here.
Keywords: fil; region; ltd; fil 200 ... See more keywords
THU0144 DESCRIPTIVE ANALYSIS OF PREGNANCY, DELIVERY, AND LACTATION IN PATIENTS WITH RHEUMATOID ARTHRITIS FROM THE IORRA COHORT.
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DOI: 10.1136/annrheumdis-2020-eular.2692
Abstract: Background: Rheumatoid Arthritis (RA) is common in women with reproductive age. For this reason, RA treatment during pregnancy and lactation is very important. In recent years, the use of biologic disease-modifying antirheumatic drugs (bDMARDs) has… read more here.
Keywords: ltd; pregnancy; none declared; pharmaceutical ltd ... See more keywords
THU0086 FACTORS ASSOCIATED WITH TREATMENT RESPONSE IN PATIENTS WITH ELDERLY-ONSET RHEUMATOID ARTHRITIS: 3-YEAR OBSERVATION USING THE IORRA COHORT.
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DOI: 10.1136/annrheumdis-2020-eular.3115
Abstract: Background: Patients with elderly-onset rheumatoid arthritis (EORA) are on the rise in the aging or super-aging society, especially in Japan. Patients with EORA have more comorbidities than those with younger-onset RA, a higher risk of… read more here.
Keywords: ltd; none declared; pharmaceutical ltd; rheumatology ... See more keywords
POS0603 ANALYSIS OF FACTORS ASSOCIATED WITH THE EFFECTIVENESS OF ABATACEPT IN THE ORIGAMI STUDY
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DOI: 10.1136/annrheumdis-2021-eular.1028
Abstract: The ORIGAMI study is a multicenter, observational study to evaluate the effectiveness, safety, and patient-reported outcomes of abatacept (ABA) in Japanese patients with csDMARD-resistant, Simplified Disease Activity Index (SDAI)-moderate, biologic-naïve rheumatoid arthritis (RA). ABA has… read more here.
Keywords: ltd; acpa; study; disease ... See more keywords
AB0145 SMARTPHONE- AND SMARTWATCH-ACQUIRED DAILY STEPS, ACTIVITY, AND BAROMETRIC PRESSURES ASSOCIATED WITH SUBJECTIVE MEASURES OF RHEUMATOID ARTHRITIS: A PROSPECTIVE STUDY FOR RA DIGITAL PHENOTYPING
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DOI: 10.1136/annrheumdis-2021-eular.3730
Abstract: Symptoms in patients with rheumatoid arthritis (RA) are potentially influenced by exercise load and meteorological change, and often vary from day to day, especially in unstable condition of RA. Patients with RA not infrequently experience… read more here.
Keywords: vas; ltd; barometric pressure; day ... See more keywords
Phase II Trial of a Peptide Vaccine, Ocv-501 in Elderly Patients with Acute Myeloid Leukemia
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DOI: 10.1182/blood-2018-99-110013
Abstract: Introduction: In recent decades, a considerable number of tumor antigens have been characterized, including the leukemia-associated antigen, Wilm's tumor 1 (WT1). WT1 is found to be expressed at low levels in various normal tissues such… read more here.
Keywords: ltd grant; ltd; ocv 501; pharmaceutical ltd ... See more keywords
OWL833, an Orally Active Nonpeptide GLP-1 Receptor Agonist, Improves Glucose Tolerance by Increasing Insulin Secretion and Reduces Food Intake of Cynomolgus Monkeys
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DOI: 10.2337/db18-1118-p
Abstract: Activation of glucagon-like peptide-1 receptors (GLP-1R) is a promising approach for the treatment of type 2 diabetes mellitus (T2D), and several peptide analogues of GLP-1 have been successfully developed. Here we identified a new orally… read more here.
Keywords: chugai pharmaceutical; glp; self chugai; pharmaceutical ltd ... See more keywords
Effects of SGLT2 Inhibitors on Insulin Secretion and Insulin Resistance—Results from a Cross-Sectional Study
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DOI: 10.2337/db18-1187-p
Abstract: SGLT2 inhibitors lower blood glucose levels by inhibiting renal glucose reabsorption independently of insulin action. In addition, SGLT2 inhibitors are known to enhance endogenous glucose production by increasing glucagon level, despite lowering fasting glucose. However,… read more here.
Keywords: sglt2 inhibitors; study; ltd; insulin resistance ... See more keywords
Febuxostat Improves Insulin Resistance in the Skeletal Muscle In Vitro and In Vivo
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DOI: 10.2337/db18-1927-p
Abstract: Hyperuricemia is closely associated with various metabolic disorders such as diabetes, hypertension, dyslipidemia, and cardiovascular diseases. Xanthine oxidoreductase (XOR) is a key enzyme known to catalyze purines to uric acid. Febuxostat is an orally-active, potent,… read more here.
Keywords: skeletal muscle; febuxostat; ltd; effect ... See more keywords
NFIA Colocalizes with PPARgamma and Activates the Cell-Type–Specific Enhancers to Control the Brown Fat Gene Program
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DOI: 10.2337/db18-270-or
Abstract: Brown fat dissipates energy as heat by means of the uncoupling protein-1 (UCP1) on the mitochondrial inner membrane. Brown fat activity is inversely correlated with body mass index in humans, and pilot studies have shown… read more here.
Keywords: fat specific; ltd; novo nordisk; pharmaceutical ltd ... See more keywords
The Prevalence and Characteristics of Diabetic Polyneuropathy in Japanese Type 2 Diabetic Patient
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DOI: 10.2337/db18-562-p
Abstract: This study aims to investigate the prevalence and characteristics of diabetic polyneuropathy (DPN) in type 2 diabetic patients registered in the Japan Diabetes Complication and its Prevention Prospective (JDCP) study. In the JDCP study, 6,338… read more here.
Keywords: prevalence characteristics; ltd; dpn; diabetic polyneuropathy ... See more keywords