Sulfasalazine: Dissolution and Distribution in Pharmaceutically Relevant Mediums
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Chemical & Engineering Data"
DOI: 10.1021/acs.jced.6b00497
Abstract: The sulfasalazine melting temperature and molar enthalpy have been determined by the DSC method. The shake flask method has been used to measure the drug solubility in buffer solutions (pH 2.0 and 7.4), hexane, and… read more here.
Keywords: pharmaceutically relevant; dissolution distribution; sulfasalazine dissolution; distribution pharmaceutically ... See more keywords
Stereocomplementary Synthesis of Pharmaceutically Relevant Chiral 2-Aryl-Substituted Pyrrolidines Using Imine Reductases.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00802
Abstract: Exploring a collection of naturally occurring imine reductases (IREDs) identified two stereocomplementary IREDs with reducing activity toward sterically hindered 2-aryl-substituted pyrrolines. Using (R)-selective ScIR and (S)-selective SvIR, various chiral 2-aryl-substituted pyrrolidines with excellent enantioselectivity (>99%… read more here.
Keywords: pharmaceutically relevant; aryl substituted; substituted pyrrolidines; imine reductases ... See more keywords
Photo-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00072
Abstract: In recent years, photochemistry has increasingly emerged as an enabling methodology in both academia and the pharmaceutical industry. Long photolysis times and the gradual reduction of light penetration remained for many years unsolved issues for… read more here.
Keywords: chemistry; flow technology; technology chemical; photo flow ... See more keywords
Developing Pharmaceutically Relevant Pd-Catalyzed C-N Coupling Reactivity Models Leveraging High-Throughput Experimentation.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c00933
Abstract: This manuscript presents machine learning models for Pd-catalyzed C-N couplings constructed using a large, pharmaceutically relevant, structurally diverse dataset (4204 unique products) generated de novo using high-throughput experimentation. The dataset generation was enabled by the… read more here.
Keywords: developing pharmaceutically; high throughput; pharmaceutically relevant; throughput experimentation ... See more keywords
Experimental Examination of Solubility and Lipophilicity as Pharmaceutically Relevant Points of Novel Bioactive Hybrid Compounds
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196504
Abstract: The important physicochemical properties of three novel bioactive hybrid compounds with different groups (-CH3, -F and -Cl) were studied, including kinetic and thermodynamic solubility in pharmaceutically relevant solvents (buffer solutions and 1-octanol) as well as… read more here.
Keywords: partition; solubility; bioactive hybrid; hybrid compounds ... See more keywords