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Published in 2017 at "Journal of Chemical & Engineering Data"
DOI: 10.1021/acs.jced.6b00497
Abstract: The sulfasalazine melting temperature and molar enthalpy have been determined by the DSC method. The shake flask method has been used to measure the drug solubility in buffer solutions (pH 2.0 and 7.4), hexane, and…
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Keywords:
pharmaceutically relevant;
dissolution distribution;
sulfasalazine dissolution;
distribution pharmaceutically ... See more keywords
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Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00802
Abstract: Exploring a collection of naturally occurring imine reductases (IREDs) identified two stereocomplementary IREDs with reducing activity toward sterically hindered 2-aryl-substituted pyrrolines. Using (R)-selective ScIR and (S)-selective SvIR, various chiral 2-aryl-substituted pyrrolidines with excellent enantioselectivity (>99%…
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Keywords:
pharmaceutically relevant;
aryl substituted;
substituted pyrrolidines;
imine reductases ... See more keywords
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Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00072
Abstract: In recent years, photochemistry has increasingly emerged as an enabling methodology in both academia and the pharmaceutical industry. Long photolysis times and the gradual reduction of light penetration remained for many years unsolved issues for…
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Keywords:
chemistry;
flow technology;
technology chemical;
photo flow ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196504
Abstract: The important physicochemical properties of three novel bioactive hybrid compounds with different groups (-CH3, -F and -Cl) were studied, including kinetic and thermodynamic solubility in pharmaceutically relevant solvents (buffer solutions and 1-octanol) as well as…
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Keywords:
partition;
solubility;
bioactive hybrid;
hybrid compounds ... See more keywords