Pharmacokinetic and Pharmacodynamic Analysis of Critically Ill Patients Undergoing Continuous Renal Replacement Therapy With Imipenem.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2020.06.010
Abstract: PURPOSE This study explores factors that affect behavior in critically ill patients receiving continuous renal replacement therapy (CRRT) with imipenem and provides dosing regimens for these patients. METHODS A prospective, open-label study was conducted in… read more here.
Keywords: imipenem; pharmacodynamic analysis; analysis; model ... See more keywords
Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer
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DOI: 10.1016/j.cmet.2018.08.021
Abstract: Summary Late-phase clinical trials investigating metformin as a cancer therapy are underway. However, there remains controversy as to the mode of action of metformin in tumors at clinical doses. We conducted a clinical study integrating… read more here.
Keywords: pharmacodynamic analysis; integrated pharmacodynamic; metformin; breast cancer ... See more keywords
Pharmacokinetic/pharmacodynamic analysis of adjunctive perampanel in subjects with partial‐onset seizures
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neurologica Scandinavica"
DOI: 10.1111/ane.12874
Abstract: Explore perampanel pharmacokinetics (PK) in all subjects (aged ≥12 years) vs adolescents (aged ≥12 to ≤17 years) with partial‐onset seizures (POS) and identify factors explaining between‐subject variability in efficacy using a population PK/pharmacodynamic (PD) analysis. read more here.
Keywords: partial onset; perampanel; pharmacodynamic analysis; onset seizures ... See more keywords
Population pharmacokinetic and pharmacodynamic analysis of osimertinib.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e20536
Abstract: e20536Background: Osimertinib is an oral, potent, irreversible, CNS active EGFR-TKI, selective for sensitizing (EGFRm) and T790M resistance mutations, indicated for the treatment of patients with T... read more here.
Keywords: analysis osimertinib; pharmacodynamic analysis; population pharmacokinetic; pharmacokinetic pharmacodynamic ... See more keywords
Integrative population pharmacokinetic/pharmacodynamic analysis of nemonoxacin capsule in Chinese patients with community-acquired pneumonia
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.912962
Abstract: Introduction: Nemonoxacin is an innovative quinolone antibiotic for treatment of community-acquired pneumonia (CAP). As more data are available from clinical studies, it is necessary to perform an integrative pharmacokinetic/pharmacodynamic (PK/PD) analysis to support and justify… read more here.
Keywords: pharmacodynamic analysis; pharmacokinetic pharmacodynamic; 500 q24; analysis ... See more keywords
Evaluation the efficacy of optimized two-step-administration therapy with ceftazidime/avibactam for treating Extensively drug-resistance (XDR) Pseudomonas aeruginosa pulmonary infections: a Pharmacokinetic/pharmacodynamic analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Japanese journal of infectious diseases"
DOI: 10.7883/yoken.jjid.2022.289
Abstract: The objective of this pharmacokinetic (PK)/pharmacodynamic (PD) analysis was to evaluate the efficacy of different dosing regimens of ceftazidime-avibactam (CZA) for the treatment of extensively drug-resistance (XDR) Pseudomonas aeruginosa pulmonary infections by using optimized two-step-administration… read more here.
Keywords: aeruginosa pulmonary; pharmacodynamic analysis; pharmacokinetic pharmacodynamic; ceftazidime avibactam ... See more keywords