Metabolomics combined with pattern recognition and bioinformatics analysis methods for the development of pharmacodynamic biomarkers on liver fibrosis.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00093f
Abstract: The major obstacle for the development of targeted therapies is the lack of pharmacodynamic (PD) biomarkers to provide an early readout of biological activities. As the modulation of metabolites may reflect the biological changes occurring… read more here.
Keywords: pharmacodynamic biomarkers; fibrosis; liver fibrosis; combined pattern ... See more keywords
Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS
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DOI: 10.1212/wnl.0000000000009559
Abstract: Objective To identify preferred neurofilament assays and clinically validate serum neurofilament light (NfL) and phosphorylated neurofilament heavy (pNfH) as prognostic and potential pharmacodynamic biomarkers relevant to amyotrophic lateral sclerosis (ALS) therapy development. Methods In this… read more here.
Keywords: serum nfl; serum; pnfh; prognostic potential ... See more keywords
Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics
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DOI: 10.3389/fnins.2020.00807
Abstract: Genetic studies have identified variants in the LRRK2 gene as important components of Parkinson’s disease (PD) pathobiology. Biochemical and emergent biomarker studies have coalesced around LRRK2 hyperactivation in disease. Therapeutics that diminish LRRK2 activity, either… read more here.
Keywords: pharmacodynamic biomarkers; biomarkers emerging; biomarker; lrrk2 therapeutics ... See more keywords