Pharmacokinetic and pharmacodynamic considerations of antibiotics and antifungals in liver transplantation recipients
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DOI: 10.1002/lt.26517
Abstract: The liver plays a major role in drug metabolism. Liver transplantation impacts the intrinsic metabolic capability and extrahepatic mechanisms of drug disposition and elimination. Different levels of inflammation and oxidative stress during transplantation, the process… read more here.
Keywords: pharmacokinetic pharmacodynamic; transplantation; considerations antibiotics; transplantation recipients ... See more keywords
Pharmacokinetic and Pharmacodynamic Considerations for Drugs Binding to Alpha-1-Acid Glycoprotein
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DOI: 10.1007/s11095-018-2551-x
Abstract: According to the free drug hypothesis only the unbound drug is available to act at physiological sites of action, and as such the importance of plasma protein binding primarily resides in its impact on pharmacokinetics… read more here.
Keywords: alpha acid; acid glycoprotein; drug; pharmacodynamic considerations ... See more keywords