Use of pharmacodynamic modeling for Bayesian information borrowing in pediatric clinical trials.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2022.2149772
Abstract: The use of Bayesian methodology to design and analyze pediatric efficacy trials is one of the possible options to reduce their sample size. This reduction of the sample size results from the use of an… read more here.
Keywords: efficacy; information borrowing; informative prior; pharmacodynamic modeling ... See more keywords
Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of Alprazolam: Implications for Anxiety and Addiction.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15719
Abstract: AIMS Alprazolam is an anxiolytic compound that can lead to psychological and physiological dependence especially with prolonged use. This study utilized physiologically based pharmacokinetic (PBPK) and pharmacodynamic (PD) modeling to further examine the underlying mechanisms… read more here.
Keywords: based pharmacokinetic; concentration; physiologically based; release ... See more keywords
Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs
Sign Up to like & getrecommendations! Published in 2018 at "BMC Veterinary Research"
DOI: 10.1186/s12917-018-1645-3
Abstract: BackgroundThe aim of this study was to optimize the dosage regimen of tylosin against S.suis in Pigs using pharmacokinetic-pharmacodynamic (PK-PD) modeling. The antibacterial activity of tylosin against S.suis CVCC606 was investigated in Mueller Hinton (MH)… read more here.
Keywords: pharmacodynamic modeling; suis pigs; tylosin suis; tylosin ... See more keywords
Neoadjuvant therapy for locally advanced gastric cancer patients. A population pharmacodynamic modeling
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DOI: 10.1371/journal.pone.0215970
Abstract: Background Perioperative chemotherapy (CT) or neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced gastric (GC) or gastroesophageal junction cancer (GEJC) has been shown to improve survival compared to an exclusive surgical approach. However, most patients… read more here.
Keywords: risk; advanced gastric; response; pharmacodynamic modeling ... See more keywords
The pharmacokinetic-pharmacodynamic modeling and cut-off values of tildipirosin against Haemophilus parasuis
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DOI: 10.18632/oncotarget.23018
Abstract: The goal of this study was to establish the epidemiological, pharmacodynamic cut-off values, optimal dose regimens for tildipirosin against Haemophilus parasuis. The minimum inhibitory concentrations (MIC) of 164 HPS isolates were determined and SH0165 whose… read more here.
Keywords: tildipirosin haemophilus; haemophilus parasuis; pharmacodynamic modeling; cut ... See more keywords
Utilization of Pharmacokinetic/Pharmacodynamic Modeling in Pharmacoepidemiological Studies: A Systematic Review on Antiarrhythmic and Glucose-Lowering Medicines
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.908538
Abstract: Introduction: In human pharmacology, there are two important scientific branches: clinical pharmacology and pharmacoepidemiology. Pharmacokinetic/pharmacodynamic (PK/PD) modeling is important in preclinical studies and randomized control trials. However, it is rarely used in pharmacoepidemiological studies on… read more here.
Keywords: pharmacoepidemiological studies; pharmacology; pharmacokinetic pharmacodynamic; glucose lowering ... See more keywords