ADME: Assessing Pharmacokinetic-Pharmacodynamic Parameters of Oligonucleotides.
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DOI: 10.1007/978-1-4939-9670-4_19
Abstract: We describe tactics to assess pharmacokinetic (PK) and pharmacodynamic (PD) parameters of oligonucleotides. The chapter includes recommendations on the design of single-dose preclinical PK studies, preclinical PKPD studies, and toxicological studies, and on best practice… read more here.
Keywords: parameters oligonucleotides; pharmacodynamic parameters; assessing pharmacokinetic; biology ... See more keywords
Evaluation of pharmacokinetic and pharmacodynamic parameters following single dose of sitagliptin in healthy Indian males
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DOI: 10.1007/s00228-018-2433-5
Abstract: PurposeSitagliptin, a dipeptidyl peptidase (DPP)-IV inhibitor approved for the treatment of type 2 diabetes, is reported to be more efficacious in Indian patients than non-Indian patient population. The objective of the study was to evaluate… read more here.
Keywords: healthy indian; dose sitagliptin; pharmacodynamic parameters; pharmacokinetic pharmacodynamic ... See more keywords
Pharmacokinetic/pharmacodynamic parameters for treatment optimization of infection due to antibiotic resistant bacteria: a summary for practical purposes in children and adults
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DOI: 10.1080/1120009x.2017.1377909
Abstract: In the last years, there has been a tremendous increase in the incidence of bacterial infections due to resistant strains, especially multi-drug resistant Gram-negative bacilli. In Europe, a north to south and a west to… read more here.
Keywords: pharmacodynamic parameters; treatment; due antibiotic; antibiotic resistant ... See more keywords