Abstract 4464: Pharmacodynamic and predictive biomarkers of clinical responses to PD-1 inhibitor budigalimab from the first-in-human clinical trial
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DOI: 10.1158/1538-7445.am2020-4464
Abstract: Background: Programmed cell death 1 (PD-1) is a receptor upregulated on activated lymphocytes that mediates a dominant-negative checkpoint signal limiting antigen receptor-driven cellular activation. PD-1 immune checkpoint inhibitors have shown durable clinical responses in patients… read more here.
Keywords: clinical trial; inhibitor; hnscc nsclc; pharmacodynamic predictive ... See more keywords