The pharmacokinetic and pharmacodynamic properties of site‐specific pegylated genetically modified recombinant human interleukin‐11 in normal and thrombocytopenic monkeys
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.05.013
Abstract: Graphical abstract Figure. No Caption available. Abstract In order to improve the pharmacokinetic and pharmacodynamic properties of recombinant human interleukin‐11 mutein (mIL‐11) and to reduce the frequency of administration, we examined the feasibility of chemical… read more here.
Keywords: pharmacodynamic properties; recombinant human; normal thrombocytopenic; mil ... See more keywords
Glycoengineering of pertuzumab and its impact on the pharmacokinetic/pharmacodynamic properties
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DOI: 10.1038/srep46347
Abstract: Pertuzumab is an antihuman HER2 antibody developed for HER2 positive breast cancer. Glycosylation profiles are always the important issue for antibody based therapy. Previous findings have suggested the impact of glycosylation profiles on the function… read more here.
Keywords: pharmacodynamic properties; glycoengineering pertuzumab; sialic acid; pharmacokinetic pharmacodynamic ... See more keywords
Pharmacokinetic and Pharmacodynamic Properties of Metronidazole in Pediatric Patients With Acute Appendicitis: A Prospective Study.
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DOI: 10.1093/jpids/piy040
Abstract: Background Metronidazole is traditionally dosed every 6-8 hours even though in adults it has a long half-life, concentration-dependent killing, and 3-hour postantibiotic effect. Based on this logic, some pediatric hospitals adopted once-daily dosing for appendicitis,… read more here.
Keywords: pharmacodynamic properties; properties metronidazole; target attainment; metronidazole pediatric ... See more keywords
Pharmacokinetic and Pharmacodynamic Properties of a Novel Inhaled Insulin
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DOI: 10.1177/1932296816658055
Abstract: Advances in insulin treatment options over recent decades have markedly improved the management of diabetes. Despite this, glycemic control remains suboptimal in many people with diabetes. Although postprandial glucose control has been improved with the… read more here.
Keywords: insulin; pharmacodynamic properties; inhaled insulin; pharmacokinetic pharmacodynamic ... See more keywords
Atypical Pharmacodynamic Properties and Metabolic Profile of the Abused Synthetic Cannabinoid AB-PINACA: Potential Contribution to Pronounced Adverse Effects Relative to Δ9-THC
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DOI: 10.3389/fphar.2018.01084
Abstract: Recreational use of marijuana is associated with few adverse effects, but abuse of synthetic cannabinoids (SCBs) can result in anxiety, psychosis, chest pain, seizures and death. To potentially explain higher toxicity associated with SCB use,… read more here.
Keywords: atypical pharmacodynamic; pharmacodynamic properties; metabolic profile; adverse effects ... See more keywords
Pharmacokinetic and pharmacodynamic properties of pantoprazole in calves
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DOI: 10.3389/fvets.2022.1101461
Abstract: Introduction Development of abomasal ulceration is a large concern, especially within calves; however, there is a paucity of research into the use of gastro protectants in ruminant species. Proton pump inhibitors, such as pantoprazole, are… read more here.
Keywords: day; administration; pharmacokinetic pharmacodynamic; abomasal ... See more keywords
Impact of Pharmacokinetic and Pharmacodynamic Properties of Monoclonal Antibodies in the Management of Psoriasis
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DOI: 10.3390/pharmaceutics14030654
Abstract: The treatment of psoriasis has been revolutionized by the emergence of biological therapies. Monoclonal antibodies (mAb) generally have complex pharmacokinetic (PK) properties with nonlinear distribution and elimination. In recent years, several population pharmacokinetic/pharmacodynamic (PK/PD) models… read more here.
Keywords: psoriasis; impact pharmacokinetic; population; monoclonal antibodies ... See more keywords