Pharmacodynamics and pharmacokinetics of the novel synthetic opioid, U-47700, in male rats
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108195
Abstract: Novel synthetic opioids are appearing in recreational drug markets worldwide as adulterants in heroin or ingredients in counterfeit analgesic medications. 3,4-Dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) is an example of a non-fentanyl synthetic opioid linked to overdose deaths. Here,… read more here.
Keywords: opioid 47700; novel synthetic; pharmacokinetics novel; pharmacodynamics pharmacokinetics ... See more keywords
Pharmacodynamics and pharmacokinetics in older adults.
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Anaesthesiology"
DOI: 10.1097/aco.0000000000000814
Abstract: PURPOSE OF REVIEW With the growing of the aging population, increased and new methods of anesthesia and surgery allow for surgery and other interventions in older adults.Pharmacokinetics and pharmacodynamics of drugs in older adults differ… read more here.
Keywords: pharmacokinetic pharmacodynamic; older adults; population; anaesthesiology ... See more keywords
The pharmacology of blinatumomab: state of the art on pharmacodynamics, pharmacokinetics, adverse drug reactions and evaluation in clinical trials
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13741
Abstract: Bispecific drugs (BDs) belong to the family of immunotherapies along with checkpoint inhibitors and CAR‐T cells. In the field of oncology, BDs are designed to simultaneously bind a tumour antigen on the one side and… read more here.
Keywords: pharmacodynamics pharmacokinetics; pharmacology; pharmacology blinatumomab; blinatumomab state ... See more keywords
First randomized evaluation of safety, pharmacodynamics, and pharmacokinetics of BAY 1831865, an antibody targeting coagulation factor XI and factor XIa, in healthy men
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15744
Abstract: Bleeding is a clinically significant issue with all current anticoagulants. Safer antithrombotic strategies are required. read more here.
Keywords: first randomized; evaluation safety; randomized evaluation; pharmacodynamics pharmacokinetics ... See more keywords
Pharmacodynamics, pharmacokinetics, safety, and tolerability of a ready‐to‐use, room temperature, liquid stable glucagon administered via an autoinjector pen to youth with type 1 diabetes
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DOI: 10.1111/pedi.13360
Abstract: Prompt and reliable management of hypoglycemia in youth with diabetes is important to prevent serious medical complications. read more here.
Keywords: youth; diabetes pharmacodynamics; pharmacokinetics safety; pharmacodynamics pharmacokinetics ... See more keywords