Pharmacokinetics, Pharmacodynamics, and Safety of a Single Escalating Dose and Repeated Doses of Rasagiline Transdermal Patch in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.761
Abstract: A rasagiline transdermal patch can be used to offer continuous rasagiline to patients with Parkinson's disease who cannot take their usual oral medications. This was the first study to investigate the pharmacokinetics, pharmacodynamics, and safety… read more here.
Keywords: pharmacodynamics safety; patch; transdermal patch; rasagiline transdermal ... See more keywords
Pharmacokinetics, pharmacodynamics and safety assessment of multiple doses of soticlestat in healthy volunteers
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DOI: 10.1111/bcp.15225
Abstract: Soticlestat, a first‐in‐class inhibitor of cholesterol 24‐hydroxylase (also known as cytochrome P450 46A1), is currently in development for the treatment of developmental and epileptic encephalopathies. Here, we report safety, tolerability, pharmacokinetic and pharmacodynamic outcomes from… read more here.
Keywords: safety; pharmacokinetics pharmacodynamics; pharmacodynamics safety; soticlestat healthy ... See more keywords
A study on pharmacokinetics, pharmacodynamics and safety of lixisenatide in children and adolescents with type 2 diabetes
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DOI: 10.1111/pedi.13343
Abstract: The aim of this study was to investigate the pharmacokinetic, pharmacodynamic and safety profile of the glucagon‐like peptide‐1 receptor agonist, lixisenatide, for the treatment of type 2 diabetes (T2D) in pediatric individuals. read more here.
Keywords: safety; pharmacokinetics pharmacodynamics; diabetes study; pharmacodynamics safety ... See more keywords
A Critical Review of the Pharmacokinetics, Pharmacodynamics, and Safety Data of Antibiotics in Avian Species
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DOI: 10.3390/antibiotics11060741
Abstract: In avian medicine, the use of antibiotic dosing regimens based on species-specific pharmacological studies is ideal. However, due to a lack of such studies, dose extrapolation, which may cause inefficacy and toxicity, is common practice.… read more here.
Keywords: pharmacokinetics pharmacodynamics; avian species; safety data; pharmacodynamics safety ... See more keywords