Opportunities for Pharmacogenetic Testing to Guide Dosing of Medications in Youths With Medicaid
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.55707
Abstract: This cross-sectional study investigates rates of dispensing of medications with a high level of evidence for pharmacogenetic-guided testing from 2011 to 2019 among youths with Medicaid. read more here.
Keywords: testing guide; dosing medications; guide dosing; pharmacogenetic testing ... See more keywords
Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity‐score matched study
Sign Up to like & getrecommendations! Published in 2018 at "Depression and Anxiety"
DOI: 10.1002/da.22742
Abstract: Naturalistic and small randomized trials have suggested that pharmacogenetic testing may improve treatment outcomes in depression, but its cost‐effectiveness is not known. There is growing enthusiasm for personalized medicine, relying on genetic variation as a… read more here.
Keywords: anxiety; among patients; testing among; pharmacogenetic testing ... See more keywords
Cost-effectiveness Analysis of CYP2D6*10 Pharmacogenetic Testing to Guide the Adjuvant Endocrine Therapy for Postmenopausal Women with Estrogen Receptor Positive Early Breast Cancer in China
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Drug Investigation"
DOI: 10.1007/s40261-019-00842-0
Abstract: A CYP2D6 gene polymorphism is related to the effect of tamoxifen treatment in patient with estrogen-receptor positive (ER) positive breast cancer and CYP2D6*10 T/T can lead to a poor prognosis in Asian patients. Although one-off… read more here.
Keywords: adjuvant endocrine; endocrine therapy; breast cancer; pharmacogenetic testing ... See more keywords
Clinical Characteristics of a Commercial Pharmacogenetic Testing Population
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DOI: 10.1017/s1092852924001846
Abstract: Pharmacogenetic testing is becoming more common, especially to provide guidance for psychiatric medications. Over 17 psychotropic medications currently have a Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline. Several clinical trials have described PGx testing in specific… read more here.
Keywords: real world; pharmacogenetic testing; commercial pgx; population ... See more keywords
Integrating pharmacogenetic testing into primary care
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Precision Medicine and Drug Development"
DOI: 10.1080/23808993.2017.1398046
Abstract: ABSTRACT Introduction: Pharmacogenetic (PGx) testing has greatly expanded due to enhanced understanding of the role of genes in drug response and advances in DNA-based testing technology development. As many primary care visits result in a… read more here.
Keywords: medicine; primary care; pharmacogenetic testing; integrating pharmacogenetic ... See more keywords
A survey on the perspectives of Irish pharmacists on the implementation of pharmacogenetics into pharmacy practice
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Pharmacy Practice"
DOI: 10.1093/ijpp/riae013.076
Abstract: Pharmacogenetics is the use of an individual’s genetic data to determine their response to a drug.[1] The incorporation of pharmacogenetic information into the prescribing process has the potential to improve patient outcomes by reducing adverse… read more here.
Keywords: survey; pharmacogenetic testing; response; pharmacy practice ... See more keywords
Public preferences for pharmacogenetic testing in the NHS: Embedding a discrete choice experiment within service design to better meet user needs
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.16058
Abstract: Genetic testing can be used to improve the safety and effectiveness of commonly prescribed medicines—a concept known as pharmacogenetics. This study aimed to quantify members of the UK public's preferences for a pharmacogenetic service to… read more here.
Keywords: preferences pharmacogenetic; testing nhs; public preferences; nhs embedding ... See more keywords
Pharmacogenetic testing among patients with depression in a US managed care population
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13279
Abstract: Actionable drug–gene pairs relevant to depression treatment include CYP2D6 and CYP2C19 with specific antidepressants. While clinical use of pharmacogenetic testing is growing, little is known about pharmacogenetic testing for depression treatment in managed care. We… read more here.
Keywords: pharmacogenetic testing; managed care; cyp2d6 cyp2c19; depression ... See more keywords
Real‐World Utilization of Medications With Pharmacogenetic Recommendations in Older Adults: A Scoping Review
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DOI: 10.1111/cts.70126
Abstract: Pharmacogenetic testing provides patient genotype information which could influence medication selection and dosing for optimal patient care. Insurance coverage for pharmacogenetic testing varies widely. A better understanding of the commonly used medications with clinically important… read more here.
Keywords: review; real world; pharmacogenetic testing; pharmacogenetic recommendations ... See more keywords
Therapeutic drug monitoring vs. pharmacogenetic testing in the context of elevated olanzapine concentrations and prior clozapine intolerability: a case study
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DOI: 10.1186/s12888-024-06319-5
Abstract: Strong evidence for therapeutic drug monitoring exists for olanzapine and clozapine, however, olanzapine therapeutic drug monitoring is often underutilized. Evidence for pharmacogenomic-guided dosing of antipsychotics is not as robust, especially for cytochrome P450 1A2 metabolized… read more here.
Keywords: pharmacogenetic testing; clozapine; drug monitoring; therapeutic drug ... See more keywords
Clinician perspectives on preemptive pharmacogenetic testing to guide chemotherapy dosing in patients with gastrointestinal malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.3_suppl.54
Abstract: 54Background: Pharmacogenetic (PGx) testing for germline variants in the DPYD and UGT1A1 genes can be used to guide fluoropyrimidine and irinotecan dosing, respectively. Despite the known associati... read more here.
Keywords: clinician perspectives; guide chemotherapy; preemptive pharmacogenetic; testing guide ... See more keywords