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   Articles with "pharmacogenetic testing" as a keyword



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Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity‐score matched study

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recommendations! Published in 2018 at "Depression and Anxiety"

DOI: 10.1002/da.22742

Abstract: Naturalistic and small randomized trials have suggested that pharmacogenetic testing may improve treatment outcomes in depression, but its cost‐effectiveness is not known. There is growing enthusiasm for personalized medicine, relying on genetic variation as a… read more here.

Keywords: anxiety; among patients; testing among; pharmacogenetic testing ... See more keywords
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Cost-effectiveness Analysis of CYP2D6*10 Pharmacogenetic Testing to Guide the Adjuvant Endocrine Therapy for Postmenopausal Women with Estrogen Receptor Positive Early Breast Cancer in China

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recommendations! Published in 2019 at "Clinical Drug Investigation"

DOI: 10.1007/s40261-019-00842-0

Abstract: A CYP2D6 gene polymorphism is related to the effect of tamoxifen treatment in patient with estrogen-receptor positive (ER) positive breast cancer and CYP2D6*10 T/T can lead to a poor prognosis in Asian patients. Although one-off… read more here.

Keywords: adjuvant endocrine; endocrine therapy; breast cancer; pharmacogenetic testing ... See more keywords
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Integrating pharmacogenetic testing into primary care

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recommendations! Published in 2017 at "Expert Review of Precision Medicine and Drug Development"

DOI: 10.1080/23808993.2017.1398046

Abstract: ABSTRACT Introduction: Pharmacogenetic (PGx) testing has greatly expanded due to enhanced understanding of the role of genes in drug response and advances in DNA-based testing technology development. As many primary care visits result in a… read more here.

Keywords: medicine; primary care; pharmacogenetic testing; integrating pharmacogenetic ... See more keywords
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Pharmacogenetic testing among patients with depression in a US managed care population

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recommendations! Published in 2022 at "Clinical and Translational Science"

DOI: 10.1111/cts.13279

Abstract: Actionable drug–gene pairs relevant to depression treatment include CYP2D6 and CYP2C19 with specific antidepressants. While clinical use of pharmacogenetic testing is growing, little is known about pharmacogenetic testing for depression treatment in managed care. We… read more here.

Keywords: pharmacogenetic testing; managed care; cyp2d6 cyp2c19; depression ... See more keywords

Clinician perspectives on preemptive pharmacogenetic testing to guide chemotherapy dosing in patients with gastrointestinal malignancies.

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recommendations! Published in 2021 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2021.39.3_suppl.54

Abstract: 54Background: Pharmacogenetic (PGx) testing for germline variants in the DPYD and UGT1A1 genes can be used to guide fluoropyrimidine and irinotecan dosing, respectively. Despite the known associati... read more here.

Keywords: clinician perspectives; guide chemotherapy; preemptive pharmacogenetic; testing guide ... See more keywords
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Development of a point-of-care genetic test for effective treatment of ischaemic stroke: an early model-based cost-effectiveness analysis

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recommendations! Published in 2023 at "Wellcome Open Research"

DOI: 10.12688/wellcomeopenres.19202.1

Abstract: Background: People who have experienced a stroke are at high risk of recurrent strokes. Clopidogrel is prescribed to people who have had a non-cardioembolic stroke. There is evidence that clopidogrel is not effective for patients… read more here.

Keywords: pharmacogenetic testing; point care; cost; analysis ... See more keywords
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Economic Value of Pharmacogenetic Testing for Cancer Drugs with Clinically Relevant Drug-Gene Associations: A Systematic Literature Review.

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recommendations! Published in 2019 at "Journal of managed care & specialty pharmacy"

DOI: 10.18553/jmcp.2019.25.2.260

Abstract: BACKGROUND Pharmacogenetic testing can provide predictive insights about the efficacy and safety of drugs used in cancer treatment. Although many drug-gene associations have been reported in the literature, the strength of evidence supporting each association… read more here.

Keywords: drug gene; drug; gene associations; pharmacogenetic testing ... See more keywords
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Pharmacogenetic testing for NAT2 genotypes in a Tanzanian population across the lifespan to guide future personalized isoniazid dosing.

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recommendations! Published in 2022 at "Tuberculosis"

DOI: 10.2139/ssrn.4087384

Abstract: Despite updated recommendations for weight-based isoniazid dosing in children with drug-susceptible tuberculosis (TB) and higher dose isoniazid in regimens for adults with drug-resistant TB, individual pharmacokinetic variability can lead to sub-target isoniazid exposure. Host pharmacogenetics… read more here.

Keywords: pharmacogenetic testing; personalized isoniazid; guide; isoniazid dosing ... See more keywords
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Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines

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recommendations! Published in 2017 at "Annals of Laboratory Medicine"

DOI: 10.3343/alm.2017.37.2.180

Abstract: Pharmacogenetic testing for clinical applications is steadily increasing. Correct and adequate use of pharmacogenetic tests is important to reduce unnecessary medical costs and adverse patient outcomes. This document contains recommended pharmacogenetic testing guidelines for clinical… read more here.

Keywords: medicine; clinical pharmacogenetic; medicine clinical; application ... See more keywords
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Pharmacogenetic Testing for Prevention of Severe Cutaneous Adverse Drug Reactions

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recommendations! Published in 2020 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2020.00969

Abstract: Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), are idiosyncratic and unpredictable drug-hypersensitivity reactions with a high-mortality rate ranging from… read more here.

Keywords: severe cutaneous; cutaneous adverse; prevention severe; drug ... See more keywords
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Variant Interpretation in Current Pharmacogenetic Testing

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recommendations! Published in 2020 at "Journal of Personalized Medicine"

DOI: 10.3390/jpm10040204

Abstract: In the current marketplace, there are now more than a dozen commercial companies providing pharmacogenetic tests. Each company varies in the panel of genes they test and the variants they are able to screen for.… read more here.

Keywords: medicine; current pharmacogenetic; pharmacogenetic testing; interpretation current ... See more keywords