Pharmacogenetic Variants and Plasma Concentrations of Antiseizure Drugs
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.25593
Abstract: Key Points Question Are variants of genes encoding drug metabolizing enzymes associated with plasma concentration of antiseizure drugs? Findings This systematic review and meta-analysis of 98 studies involving 12 543 participants provided quantification of differences in… read more here.
Keywords: concentrations antiseizure; pharmacogenetic variants; plasma concentrations; variants plasma ... See more keywords
The role of candidate pharmacogenetic variants in determining valproic acid efficacy, toxicity and concentrations in patients with epilepsy
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1483723
Abstract: Background Antiseizure medications (ASM) exhibit considerable interindividual variability in terms of efficacy and adverse events. Genetic variation is thought to contribute to these differences in clinical outcomes. Specifically, the response to valproic acid (VPA), a… read more here.
Keywords: pharmacogenetic variants; treatment; candidate pharmacogenetic; efficacy ... See more keywords
Can Pharmacogenetic Variants in TPMT, MTHFR and SLCO1B1 Genes Be Used as Potential Markers of Outcome Prediction in Systemic Sclerosis Patients?
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108538
Abstract: Systemic sclerosis (SSc) is a rare connective tissue disorder with highest morbidity and mortality among rheumatologic diseases. Disease progression is highly heterogeneous between patients, implying a strong need for individualization of therapy. Four pharmacogenetic variants,… read more here.
Keywords: systemic sclerosis; patients ssc; pharmacogenetic variants; slco1b1 ... See more keywords
Efficacy of computational predictions of the functional effect of idiosyncratic pharmacogenetic variants
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DOI: 10.7717/peerj.11774
Abstract: Background Pharmacogenetic variation is important to drug responses through diverse and complex mechanisms. Predictions of the functional impact of missense pharmacogenetic variants primarily rely on the degree of sequence conservation between species as a primary… read more here.
Keywords: predictions functional; pharmacogenetic variants; target; drug ... See more keywords