Pharmacogenomic-guided dosing of fluoropyrimidines beyond DPYD: time for a polygenic algorithm?
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DOI: 10.3389/fphar.2023.1184523
Abstract: Fluoropyrimidines are chemotherapeutic agents widely used for the treatment of various solid tumors. Commonly prescribed FPs include 5-fluorouracil (5-FU) and its oral prodrugs capecitabine (CAP) and tegafur. Bioconversion of 5-FU prodrugs to 5-FU and subsequent… read more here.
Keywords: guided dosing; toxicity; beyond dpyd; dosing guidelines ... See more keywords