Pharmacokinetic Characterization of [18F]UCB-H PET Radiopharmaceutical in the Rat Brain.
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DOI: 10.1021/acs.molpharmaceut.7b00235
Abstract: The synaptic vesicle glycoprotein 2A (SV2A), a protein essential to the proper nervous system function, is found in presynaptic vesicles. Thus, SV2A targeting, using dedicated radiotracers combined with positron emission tomography (PET), allows the assessment… read more here.
Keywords: 18f ucb; characterization 18f; rat brain; brain ... See more keywords
Pharmacokinetic characterization of anhuienoside C and its deglycosylated metabolites in rats
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DOI: 10.1080/00498254.2016.1241452
Abstract: Abstract 1. Anhuienoside C (AC), a triterpenoid saponin derived from the traditional Chinese medicine (TCM) “Di Wu”, has significant anti-inflammatory and anti-rheumatoid arthritis activities. Here we aimed to characterize the pharmacokinetics of AC and its deglycosylated… read more here.
Keywords: metabolites rats; characterization anhuienoside; deglycosylated metabolites; mdck mdr1 ... See more keywords
Pharmacokinetic characterization, benefits and barriers of subcutaneous administration of monoclonal antibodies in oncology
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DOI: 10.1177/10781552221137702
Abstract: Objective Therapeutic monoclonal antibodies in oncology are slowly becoming the dominant treatment option for many different cancer types. The main route of administration, infusion, requires extensive product preparations, patient hospitalization and close monitoring. Patient comfort… read more here.
Keywords: characterization benefits; oncology; administration; antibodies oncology ... See more keywords
Pharmacokinetic Characterization of Supinoxin and Its Physiologically Based Pharmacokinetic Modeling in Rats
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DOI: 10.3390/pharmaceutics13030373
Abstract: Supinoxin is a novel anticancer drug candidate targeting the Y593 phospho-p68 RNA helicase, by exhibiting antiproliferative activity and/or suppression of tumor growth. This study aimed to characterize the in vitro and in vivo pharmacokinetics of… read more here.
Keywords: based pharmacokinetic; characterization supinoxin; physiologically based; supinoxin ... See more keywords