A pharmacokinetic comparison of homodimer ARB-92 and heterodimer ARB-89: novel, potent antimalarial candidates derived from 7β-hydroxyartemisinin
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-017-0352-6
Abstract: The ultimate goal of this study was to identify an orally active, affordable, potent and safe antimalarial drug based on the natural product artemisinin. During these efforts, a series of novel 7β-hydroxyartemisinin analogs were synthesized… read more here.
Keywords: pharmacokinetic comparison; comparison homodimer; homodimer arb; arb heterodimer ... See more keywords
Quantification of Acipimox in Plasma and Tissues by LC–MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia
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DOI: 10.3390/molecules27196413
Abstract: This study aimed to evaluate the pharmacokinetics of acipimox in rats under simulated high altitude hypoxia conditions. A sensitive and reliable LC–MS/MS method has been established for the quantitation of acipimox in rat plasma and… read more here.
Keywords: quantification acipimox; acipimox plasma; plasma tissues; hypoxia ... See more keywords