Metabolic Pathway of Icotinib In Vitro: The Differential Roles of CYP3A4, CYP3A5, and CYP1A2 on Potential Pharmacokinetic Drug-Drug Interaction.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.12.007
Abstract: Icotinib is the first self-developed small molecule drug in China for targeted therapy of non-small cell lung cancer. To date, systematic studies on the pharmacokinetic drug-drug interaction of icotinib were limited. By identifying metabolite generated… read more here.
Keywords: drug interaction; drug; cyp3a5 cyp1a2; pharmacokinetic drug ... See more keywords
Pharmacokinetic and Drug Metabolism Properties of Novel Therapeutic Modalities
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DOI: 10.1124/dmd.119.088708
Abstract: The discovery and development of novel pharmaceutical therapies is rapidly transitioning from a small molecule–dominated focus to a more balanced portfolio consisting of small molecules, monoclonal antibodies, engineered proteins (modified endogenous proteins, bispecific antibodies, and… read more here.
Keywords: metabolism; properties novel; metabolism properties; pharmacokinetic drug ... See more keywords
Pharmacokinetic Drug Interaction Between Amlodipine and Tadalafil: An Open-Label, Randomized, Multiple-Dose Crossover Study in Healthy Male Volunteers
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DOI: 10.2147/dddt.s348897
Abstract: Purpose The combined administration of tadalafil, a phosphodiesterase-5 inhibitor, and amlodipine, a calcium channel blocker, can be a promising therapeutic option for hypertension patients with erectile dysfunction. This study aimed to examine the pharmacokinetic drug… read more here.
Keywords: tadalafil; drug interaction; study; pharmacokinetic drug ... See more keywords
Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats
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DOI: 10.3390/pharmaceutics13122172
Abstract: A combination of the tyrosine kinase inhibitor—sorafenib—and the opioid analgesic—morphine—can be found in the treatment of cancer patients. Since both are substrates of P-glycoprotein (P-gp), and sorafenib is also an inhibitor of P-gp, their co-administration… read more here.
Keywords: pharmacokinetic drug; sorafenib morphine; morphine; study ... See more keywords