Assessment of Pharmacokinetic Interaction Between Letermovir and Fluconazole in Healthy Participants
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DOI: 10.1002/cpdd.852
Abstract: Letermovir is a prophylactic agent for cytomegalovirus infection and disease in adult cytomegalovirus‐seropositive recipients of allogeneic hematopoietic stem cell transplant. As the antifungal agent fluconazole is administered frequently in transplant recipients, a drug–drug interaction study… read more here.
Keywords: pharmacokinetic interaction; interaction letermovir; assessment pharmacokinetic; coadministration fluconazole ... See more keywords
Pharmacokinetic Interaction Between Telmisartan and Rosuvastatin/Ezetimibe After Multiple Oral Administration in Healthy Subjects
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DOI: 10.1007/s12325-020-01592-8
Abstract: Telmisartan, rosuvastatin and ezetimibe are commonly recommended as combination therapies. However, the pharmacokinetic (PK) interaction among these therapeutic drugs has not been clearly reported. The objective of this study was to investigate possible interactions between… read more here.
Keywords: pharmacokinetic interaction; rosuvastatin ezetimibe; telmisartan rosuvastatin; rosuvastatin ... See more keywords
Herb–herb pharmacokinetic interaction between Glehniae radix and Ophiopogonis radix in rats using superimposed multiple product ion (SMPI) LC-HR-MS/MS
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DOI: 10.1039/c7ra02554h
Abstract: The combination of Glehniae radix (Beishashen, GR) and Ophiopogonis radix (Maidong, OR) has long been widely used as a traditional Chinese medicine (TCM) herb pair for the treatment of respiratory system and digestive system diseases.… read more here.
Keywords: pharmacokinetic interaction; glehniae radix; radix; herb ... See more keywords
In Vivo Evaluation of the Pharmacokinetic Interaction between Levothyroxine and Amiodarone in Rat Plasma: Evaluation of Importance of Therapeutic Drug Monitoring during Co-Therapy.
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DOI: 10.1093/chromsci/bmad034
Abstract: Amiodarone-induced thyrotoxicosis (AIT) is a common condition in patients who are receiving amiodarone for cardiac arrhythmia. This risk is elevated in iodine-deficient regions. Levothyroxine is the standard treatment for patients with hypothyroidism. This investigation is… read more here.
Keywords: evaluation; pharmacokinetic interaction; rat plasma; levothyroxine ... See more keywords
The pharmacokinetic interaction between ivacaftor and ritonavir in healthy volunteers
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DOI: 10.1111/bcp.13324
Abstract: AIMS The aim of this study was to determine the pharmacokinetic interaction between ivacaftor and ritonavir. METHODS A liquid chromatography mass spectrometry (LC-MS) method was developed for the measurement of ivacaftor in plasma. An open-label,… read more here.
Keywords: ivacaftor; pharmacokinetic interaction; ivacaftor ritonavir; interaction ivacaftor ... See more keywords