Amenamevir: Studies of Potential CYP3A‐Mediated Pharmacokinetic Interactions With Midazolam, Cyclosporine, and Ritonavir in Healthy Volunteers
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.586
Abstract: Amenamevir (formerly ASP2151) is a helicase‐primase inhibitor being developed for the treatment of herpesvirus infection. Amenamevir is both a substrate and inducer of cytochrome P450 (CYP) 3A4. Three studies were done in healthy volunteers to… read more here.
Keywords: cyp3a mediated; cyp3a; healthy volunteers; geometric mean ... See more keywords
Dysregulation of Endobiotic Homeostasis Mechanisms: Novel Insights into Adverse Pharmacokinetic Interactions between Illicit Substances and Clinical Drugs.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00726
Abstract: Many patients with a variety of medical conditions take illicit substances concomitantly with clinical drugs. This concomitant usage can lead to life-threatening adverse events. Despite the evidence that these adverse events can be caused by… read more here.
Keywords: substances clinical; endobiotic homeostasis; illicit substances; pharmacokinetic interactions ... See more keywords
Pharmacokinetic interactions of modern antiretroviral therapy
Sign Up to like & getrecommendations! Published in 2021 at "AIDS"
DOI: 10.1097/qad.0000000000002950
Abstract: Drug--drug interactions (DDIs) have been a clinical challenge in HIV medicine for over two decades. The newer antiretroviral drugs (ARTs) have significantly fewer DDIs than protease inhibitors and boosted integrase inhibitors (INSTIs). The lower propensity… read more here.
Keywords: modern antiretroviral; medicine; antiretroviral therapy; interactions modern ... See more keywords
Pharmacokinetic interactions and dosing rationale for antiepileptic drugs in adults and children
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13400
Abstract: AIMS Population pharmacokinetic modelling has been widely used across many therapeutic areas to identify sources of variability, which are incorporated into models as covariate factors. Despite numerous publications on pharmacokinetic drug-drug interactions (DDIs) between antiepileptic… read more here.
Keywords: dosing rationale; interactions dosing; pharmacokinetic interactions; rationale antiepileptic ... See more keywords
No apparent pharmacokinetic interactions were found between henagliflozin: A novel sodium‐glucose co‐transporter 2 inhibitor and glimepiride in healthy Chinese male subjects
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13659
Abstract: Henagliflozin is a novel selective sodium‐glucose co‐transporter 2 (SGLT2) inhibitor with similar inhibitory effect to ertugliflozin. Glimepiride is widely used to treat type 2 diabetes mellitus (T2DM) with few cardiovascular side effects. In the present… read more here.
Keywords: glucose transporter; henagliflozin novel; sodium glucose; pharmacokinetic interactions ... See more keywords
Clinical pharmacokinetic interactions between lamotrigine and hormonal contraceptives in bipolar I disorder
Sign Up to like & getrecommendations! Published in 2017 at "Psychiatry and Clinical Neurosciences"
DOI: 10.1111/pcn.12512
Abstract: Lamotrigine (LTG) is prescribed for bipolar disorder and epilepsy. Oral contraceptives (OCs) containing estrogen may reciprocally decrease the concentration of LTG. We present a case of a female patient with bipolar I disorder with prolonged… read more here.
Keywords: disorder; interactions lamotrigine; lamotrigine hormonal; bipolar disorder ... See more keywords
Pharmacokinetic Interactions of a Licorice Dietary Supplement with Cytochrome P450 Enzymes in Female Participants
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DOI: 10.1124/dmd.122.001050
Abstract: Licorice, the roots and rhizomes of Glycyrrhiza glabra L., has been used as a medicinal herb, herbal adjuvant, and flavoring agent since ancient times. Recently, licorice extracts have become popular as dietary supplements used by… read more here.
Keywords: p450 enzymes; pharmacokinetic interactions; cytochrome p450; p450 ... See more keywords
Pharmacokinetic interactions study between carvedilol and some antidepressants in rat liver microsomes – a comparative study
Sign Up to like & getrecommendations! Published in 2019 at "Medicine and Pharmacy Reports"
DOI: 10.15386/mpr-1225
Abstract: Background and aims Cardiovascular diseases and depressive disorders are some of the most frequent diseases. The probability of concomitant prescription of antihypertensive and antidepressive medication is increasing. The aim of this study was to investigate… read more here.
Keywords: inhibitor; carvedilol; pharmacokinetic interactions; liver microsomes ... See more keywords
Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions? Observations and introspection of the bioanalysis
Sign Up to like & getrecommendations! Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s137116
Abstract: and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove… read more here.
Keywords: interactions glimepiride; drug design; drug; design development ... See more keywords
Herb-Drug Interactions and Their Impact on Pharmacokinetics: an Update.
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DOI: 10.2174/1389200224666230116113240
Abstract: Herb medicine has a long history of application and is still used worldwide. With the development of complementary and alternative medicine, the interaction between herb and drugs has attracted more and more attention. Herb-drug interactions… read more here.
Keywords: interactions impact; pharmacokinetic interactions; drug interactions; herb drug ... See more keywords
Pharmacokinetic Interactions Between Antiseizure and Psychiatric Medications.
Sign Up to like & getrecommendations! Published in 2022 at "Current neuropharmacology"
DOI: 10.2174/1570159x20666220524121645
Abstract: Antiseizure medications and drugs for psychiatric diseases are frequently used in combination. In this context pharmacokinetic interactions between these drugs may occur. The vast majority of these interactions are primarily observed at a metabolic level… read more here.
Keywords: antiseizure medications; antiseizure psychiatric; drugs psychiatric; pharmacokinetic interactions ... See more keywords