Interchangeability of Generic Drugs: A Nonparametric Pharmacokinetic Model of Gabapentin Generic Drugs
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DOI: 10.1002/cpt.1023
Abstract: Substitution by generic drugs is allowed when bioequivalence to the originator drug has been established. However, it is known that similarity in exposure may not be achieved at every occasion for all individual patients when… read more here.
Keywords: pharmacokinetic model; model gabapentin; interchangeability generic; generic drugs ... See more keywords
A physiologically based pharmacokinetic model of vitamin D
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DOI: 10.1002/jat.3489
Abstract: Despite the plethora of studies discussing the benefits of vitamin D on physiological functioning, few mathematical models of vitamin D predict the response of the body on low‐concentration supplementation of vitamin D under sunlight‐restricted conditions.… read more here.
Keywords: pharmacokinetic model; based pharmacokinetic; physiologically based; model ... See more keywords
A population pharmacokinetic model taking into account protein binding for the sustained-release granule formulation of valproic acid in children with epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2444-2
Abstract: PurposeThe objective of this work was to develop a population pharmacokinetic model for a prolonged-release granule formulation of valproic acid (VPA) in children with epilepsy and to determine the doses providing a VPA trough concentration… read more here.
Keywords: release granule; pharmacokinetic model; granule formulation; formulation valproic ... See more keywords
Physiologically-based pharmacokinetic model for 2,4-dinitrophenol.
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DOI: 10.1007/s10928-022-09806-y
Abstract: New approaches in drug development are needed to address the growing epidemic of obesity as the prevalence of obesity increases worldwide. 2,4-Dinitrophenol (DNP) is an oxidative phosphorylation uncoupling agent that was widely used in the… read more here.
Keywords: model dinitrophenol; based pharmacokinetic; model; pharmacokinetic model ... See more keywords
Development of a joint population pharmacokinetic model of ezetimibe and its conjugated metabolite
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DOI: 10.1016/j.ejps.2018.11.018
Abstract: &NA; Ezetimibe (EZE) is an extensively used antihyperlipidemic drug with an important cholesterol lowering activity. It undergoes extensive first‐pass metabolism to form its active glucuronide metabolite (EZEG). Both drugs exhibit complex pharmacokinetic profiles attributed mainly… read more here.
Keywords: development joint; pharmacokinetic model; population pharmacokinetic; joint population ... See more keywords
A pharmacokinetic model optimized by covariates for propofol target-controlled infusion in dogs.
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary anaesthesia and analgesia"
DOI: 10.1016/j.vaa.2019.04.009
Abstract: OBJECTIVE To develop a population pharmacokinetic model for propofol target-controlled infusion (TCI) in dogs and to evaluate its performance for use in the clinical setting. STUDY DESIGN Prospective clinical study. ANIMALS A group of 40… read more here.
Keywords: pharmacokinetic model; infusion; performance; target controlled ... See more keywords
Providing context for phosphatidylethanol as a biomarker of alcohol consumption with a pharmacokinetic model
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DOI: 10.1016/j.yrtph.2018.01.029
Abstract: ABSTRACT Phosphatidylethanol (PEth) is increasingly used as a biomarker of heavy drinking. Many different forms of PEth can form in red blood cell membranes from the action of the enzyme phospholipase D. PEth has a… read more here.
Keywords: alcohol consumption; pharmacokinetic model; biomarker; peth ... See more keywords
The illusion of informed consent
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DOI: 10.1111/anae.14002
Abstract: United States of America 2008; 105: 1309–14. 2. Pandit JJ. Monitoring (un)consciousness: the implications of a new definition of ‘anaesthesia’. Anaesthesia 2014; 69: 801–7. 3. Sep ulveda V PO, Carrasco E, Tapia LF, et al.… read more here.
Keywords: pharmacokinetic model; propofol; pharmacokinetic models; anaesthesia ... See more keywords
A semiphysiological population pharmacokinetic model of agomelatine and its metabolites in Chinese healthy volunteers
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DOI: 10.1111/bcp.13902
Abstract: Agomelatine is an antidepressant for major depressive disorders. It undergoes extensive first‐pass hepatic metabolism and displays irregular absorption profiles and large interindividual variability (IIV) and interoccasion variability of pharmacokinetics. The objective of this study was… read more here.
Keywords: pharmacokinetic model; population pharmacokinetic; model agomelatine; semiphysiological population ... See more keywords
A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk
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DOI: 10.1111/bcp.14278
Abstract: Escitalopram (SCIT) is frequently prescribed to breastfeeding women. Available information on SCIT excretion into breast milk is based on heterogeneous and incomplete data. A population pharmacokinetic model that aimed to better characterize maternal and infant… read more here.
Keywords: population pharmacokinetic; pharmacokinetic model; breast milk; escitalopram ... See more keywords
Development of a new pharmacokinetic model for target-concentration controlled infusion of cefoxitin as a prophylactic antibiotic in colorectal surgical patients.
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DOI: 10.1111/bcp.14883
Abstract: AIMS There are several limitations to the existing method of administering cefoxitin as a prophylactic antibiotic, and the limitations may be overcome by applying the target-concentration controlled infusion (TCI) method. Population pharmacokinetic parameters are required… read more here.
Keywords: pharmacokinetic model; cefoxitin; method; surgical patients ... See more keywords