The Impact of Dexamethasone and Prednisone on Apixaban and Rivaroxaban Exposure in COVID‐19 Patients: A Physiologically Based Pharmacokinetic Modeling Study
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3491
Abstract: Dexamethasone (DEX) is currently the treatment of choice for patients with oxygen‐dependent COVID‐19. It has been observed, primarily in vitro, that dexamethasone induces the expression of CYP3A and the ABCB1 gene, which encodes P‐glycoprotein (P‐gp).… read more here.
Keywords: covid; dex; based pharmacokinetic; pharmacokinetic modeling ... See more keywords
Hepatic function imaging using dynamic Gd‐EOB‐DTPA enhanced MRI and pharmacokinetic modeling
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DOI: 10.1002/mrm.26520
Abstract: To determine whether pharmacokinetic modeling parameters with different output assumptions of dynamic contrast–enhanced MRI (DCE‐MRI) using Gd‐EOB‐DTPA correlate with serum‐based liver function tests, and compare the goodness of fit of the different output assumptions. read more here.
Keywords: pharmacokinetic modeling; hepatic function; enhanced mri; eob dtpa ... See more keywords
Adverse Reactions in a Phase 1 Trial of the Anti-Malarial DM1157: An Example of Pharmacokinetic Modeling and Simulation Guiding Clinical Trial Decisions
Sign Up to like & getrecommendations! Published in 2022 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-022-00605-z
Abstract: There is an urgent need to develop new drugs to treat malaria due to increasing resistance to first-line therapeutics targeting the causative organism, Plasmodium falciparum (P. falciparum). One drug candidate is DM1157, a small molecule… read more here.
Keywords: modeling simulation; dm1157; phase trial; trial ... See more keywords
State-of-the-Art Review on Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-018-0677-y
Abstract: Physiologically based pharmacokinetic modeling and simulation is an important tool for predicting the pharmacokinetics, pharmacodynamics, and safety of drugs in pediatrics. Physiologically based pharmacokinetic modeling is applied in pediatric drug development for first-time-in-pediatric dose selection,… read more here.
Keywords: pharmacokinetic modeling; drug development; based pharmacokinetic; physiologically based ... See more keywords
Exploration of Reduced Doses and Short-Cycle Therapy for Darunavir/Cobicistat in Patients with HIV Using Population Pharmacokinetic Modeling and Simulations
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-020-00920-z
Abstract: Protease inhibitors such as darunavir are an important therapeutic option in the anti-human immunodeficiency virus arsenal. Current dosage guidelines recommend using cobicistat- or ritonavir-boosted darunavir 800 mg every 24 h (q24h) in protease inhibitor-naïve patients,… read more here.
Keywords: pharmacokinetic modeling; darunavir; population pharmacokinetic; using population ... See more keywords
Brain amyloid PET interpretation approaches: from visual assessment in the clinic to quantitative pharmacokinetic modeling
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Translational Imaging"
DOI: 10.1007/s40336-017-0257-4
Abstract: PurposeCerebral β-amyloid burden can be measured by positron emission tomography (PET) tracers, including 11C-Pittsburgh Compound B (11C-PiB) and three fluorinated tracers that have been approved by regulatory agencies. This review focuses on the current clinical… read more here.
Keywords: pharmacokinetic modeling; interpretation; 11c pib; amyloid pet ... See more keywords
Physiologically Based Pharmacokinetic Modeling of Nanoparticles.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.10.037
Abstract: Nanoparticles are frequently designed to improve the pharmacokinetics profiles and tissue distribution of small molecules to prolong their systemic circulation, target specific tissue, or widen the therapeutic window. The multifunctionality of nanoparticles is frequently presented… read more here.
Keywords: pharmacokinetic modeling; disposition; based pharmacokinetic; pbpk modeling ... See more keywords
Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.10.056
Abstract: The insidious nature of Zika virus (ZIKV) infections can have a devastating consequence for fetal development. Recent reports have highlighted that chloroquine (CQ) is capable of inhibiting ZIKV endocytosis in brain cells. We applied pharmacokinetic… read more here.
Keywords: pharmacokinetic modeling; zika virus; pregnancy; chloroquine ... See more keywords
More Than a Gut Feeling—A Combination of Physiologically Driven Dissolution and Pharmacokinetic Modeling as a Tool for Understanding Human Gastric Motility
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DOI: 10.1021/acs.molpharmaceut.4c00117
Abstract: In vivo studies of formulation performance with in vitro and/or in silico simulations are often limited by significant gaps in our knowledge of the interaction between administered dosage forms and the human gastrointestinal tract. This… read more here.
Keywords: pharmacokinetic modeling; methodology; gastric motility; dissolution ... See more keywords
Pharmacokinetic Modeling of the Second-Wave Phenomenon in Nanobubble-Based Contrast-Enhanced Ultrasound
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DOI: 10.1109/tbme.2022.3184266
Abstract: With a typical 100–500 nm diameter, nanobubbles are a promising new-generation ultrasound contrast agent that paves ways for several applications, such as efficient drug delivery, molecular imaging, and assessment of vascular permeability. Due to their… read more here.
Keywords: second wave; contrast; pharmacokinetic modeling; wave phenomenon ... See more keywords
Population pharmacokinetic modeling and simulations of berotralstat for prophylactic treatment of attacks of hereditary angioedema
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13233
Abstract: Hereditary angioedema (HAE) is an autosomal dominant disorder characterized by recurrent episodes of swelling of the skin, larynx, gastrointestinal tract, genitals, and extremities that can be disruptive to patient quality of life. Dysregulation of plasma… read more here.
Keywords: plasma kallikrein; hereditary angioedema; modeling simulations; population pharmacokinetic ... See more keywords