Physiologically‐based pharmacokinetic modelling of a CYP2C19 substrate, BMS‐823778, utilizing pharmacogenetic data
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DOI: 10.1111/bcp.13565
Abstract: Previous studies demonstrated direct correlation between CYP2C19 genotype and BMS‐823778 clearance in healthy volunteers. The objective of the present study was to develop a physiologically‐based pharmacokinetic (PBPK) model for BMS‐823778 and use the model to… read more here.
Keywords: based pharmacokinetic; pharmacokinetic modelling; bms 823778; physiologically based ... See more keywords
Population pharmacokinetic modelling and simulation of fremanezumab in healthy subjects and patients with migraine
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DOI: 10.1111/bcp.14096
Abstract: Fremanezumab is a fully humanized IgG2Δa/κ monoclonal antibody specific for calcitonin gene‐related peptide developed and approved for the preventive treatment of migraine in adults. The population pharmacokinetics (PK) of fremanezumab were characterized in healthy subjects… read more here.
Keywords: population pharmacokinetic; subjects patients; pharmacokinetic modelling; healthy subjects ... See more keywords
Development, Characterization, and Optimization of a Novel Abiraterone Acetate Formulation to Improve Biopharmaceutical Attributes Aided by Pharmacokinetic Modelling.
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DOI: 10.1208/s12249-021-02168-7
Abstract: Abiraterone acetate has very low bioavailability and drastic food effect to warrant a dosing regimen under fasting state only. Therefore, we aimed to develop and optimize a liquisolid compact formulation of abiraterone acetate to improve… read more here.
Keywords: abiraterone acetate; pharmacokinetic modelling; aided pharmacokinetic; formulation ... See more keywords
Physiologically Based Pharmacokinetic Modelling and Simulation to Predict the Plasma Concentration Profile of Doxorubicin
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DOI: 10.3390/pharmaceutics14030541
Abstract: Doxorubicin (DOX) is still an important anticancer agent despite its tricky pharmacokinetics (PK) and toxicity potential. The advent of systems pharmacology enables the construction of PK models able to predict the concentration profiles of drugs… read more here.
Keywords: modelling simulation; pharmacokinetic modelling; concentration; based pharmacokinetic ... See more keywords
Novel αO-conotoxin GeXIVA[1,2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment
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DOI: 10.3390/pharmaceutics14091789
Abstract: αO-conotoxin GeXIVA[1,2] was isolated in our laboratory from Conus generalis, a snail native to the South China Sea, and is a novel, nonaddictive, intramuscularly administered analgesic targeting the α9α10 nicotinic acetylcholine receptor (nAChR) with an… read more here.
Keywords: pharmacokinetic modelling; conotoxin; conotoxin gexiva; mechanistic assessment ... See more keywords