Evaluation of pharmacokinetic models for perfusion imaging with dynamic contrast‐enhanced magnetic resonance imaging in porcine skeletal muscle using low‐molecular‐weight contrast agents
Sign Up to like & getrecommendations! Published in 2018 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.26983
Abstract: Pharmacokinetic models for perfusion quantification with a low‐molecular‐weight contrast agent (LMCA) in skeletal muscle using dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) were evaluated. read more here.
Keywords: low molecular; pharmacokinetic models; contrast; magnetic resonance ... See more keywords
External evaluation of population pharmacokinetic models for continuous administration of meropenem in critically ill adult patients
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DOI: 10.1007/s00228-020-02922-z
Abstract: Beta-lactams (BL), the most commonly prescribed class of antibiotics, are recommended as the first-line therapy for multiple indications in infectious disease guidelines. Meropenem (MERO) is frequently used in intensive care units (ICU) to treat bacterial… read more here.
Keywords: pharmacokinetic models; population pharmacokinetic; external evaluation; evaluation ... See more keywords
Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers
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DOI: 10.1007/s00228-021-03104-1
Abstract: Purpose The recent repurposing of ketamine as treatment for pain and depression has increased the need for accurate population pharmacokinetic (PK) models to inform the design of new clinical trials. Therefore, the objectives of this… read more here.
Keywords: pharmacokinetic models; population pharmacokinetic; healthy volunteers; models ketamine ... See more keywords
Evaluation of pharmacokinetic models of intravenous dexmedetomidine in sedated patients under spinal anesthesia
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DOI: 10.1007/s00540-017-2424-1
Abstract: PurposeLittle information is available on the predictive ability of previously published pharmacokinetic models of dexmedetomidine in patients under spinal anesthesia. We evaluated nine published pharmacokinetic models that were constructed in different study settings.MethodsSixteen patients received… read more here.
Keywords: spinal anesthesia; pharmacokinetic models; dexmedetomidine concentrations; patients spinal ... See more keywords
Fetal Physiologically Based Pharmacokinetic Models: Systems Information on the Growth and Composition of Fetal Organs
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DOI: 10.1007/s40262-018-0685-y
Abstract: BackgroundThe growth of fetal organs is a dynamic process involving considerable changes in the anatomical and physiological parameters that can alter fetal exposure to xenobiotics in utero. Physiologically based pharmacokinetic models can be used to… read more here.
Keywords: fetal physiologically; pharmacokinetic models; based pharmacokinetic; physiologically based ... See more keywords
Population pharmacokinetics and evaluation of the predictive performance of pharmacokinetic models in critically ill patients receiving continuous infusion meropenem: a comparison of eight pharmacokinetic models
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DOI: 10.1093/jac/dky434
Abstract: Background Several population pharmacokinetic (PopPK) models for meropenem dosing in ICU patients are available. It is not known to what extent these models can predict meropenem concentrations in an independent validation dataset when meropenem is… read more here.
Keywords: receiving continuous; infusion meropenem; pharmacokinetic models; continuous infusion ... See more keywords
Dosing for Personalized Prophylaxis in Hemophilia A highly varies on the underlying Population Pharmacokinetic Models.
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DOI: 10.1097/ftd.0000000000000983
Abstract: BACKGROUND Model-informed personalized prophylaxis with factor VIII (FVIII) replacement therapy aimed at higher trough levels is becoming indispensable for patients with severe hemophilia A. This study aimed to identify the most suitable population pharmacokinetic (PK)… read more here.
Keywords: pharmacokinetic models; population; population pharmacokinetic; model ... See more keywords
The illusion of informed consent
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DOI: 10.1111/anae.14002
Abstract: United States of America 2008; 105: 1309–14. 2. Pandit JJ. Monitoring (un)consciousness: the implications of a new definition of ‘anaesthesia’. Anaesthesia 2014; 69: 801–7. 3. Sep ulveda V PO, Carrasco E, Tapia LF, et al.… read more here.
Keywords: pharmacokinetic model; propofol; pharmacokinetic models; anaesthesia ... See more keywords
A Comparative Analysis of Physiologically Based Pharmacokinetic Models for Human Immunodeficiency Virus and Tuberculosis Infections
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DOI: 10.1128/aac.00274-22
Abstract: Physiologically based pharmacokinetic (PBPK) models have gained in popularity in the last decade in both drug development and regulatory science. PBPK models differ from classical pharmacokinetic models in that they include specific compartments for tissues… read more here.
Keywords: pbpk models; based pharmacokinetic; physiologically based; drug ... See more keywords
A Review of Population Pharmacokinetic Models of Posaconazole
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DOI: 10.2147/dddt.s384637
Abstract: Abstract Posaconazole is often used for the prophylaxis and treatment of invasive fungal infections (IFI). However, intra- and inter-individual differences and drug interactions affect the efficacy and safety of posaconazole. Precision dosing of posaconazole based… read more here.
Keywords: models posaconazole; population pharmacokinetic; review population; pharmacokinetic models ... See more keywords
External Evaluation of Vancomycin Population Pharmacokinetic Models at Two Clinical Centers
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DOI: 10.3389/fphar.2021.623907
Abstract: Background: Numerous vancomycin population pharmacokinetic models in neonates have been published; however, their predictive performances remain unknown. This study aims to evaluate their external predictability and explore the factors that might affect model performance. Methods:… read more here.
Keywords: pharmacokinetic models; population pharmacokinetic; vancomycin population; performance ... See more keywords