Application of a Backpropagation Artificial Neural Network in Predicting Plasma Concentration and Pharmacokinetic Parameters of Oral Single‐Dose Rosuvastatin in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.809
Abstract: A backpropagation artificial neural network (BPANN) model was established for the prediction of the plasma concentration and pharmacokinetic parameters of rosuvastatin (RVST) in healthy subjects. The data (demographic characteristics and results of clinical laboratory tests)… read more here.
Keywords: plasma concentration; concentration pharmacokinetic; model; healthy subjects ... See more keywords
Can DCE-MRI reduce the number of PI-RADS v.2 false positive findings? Role of quantitative pharmacokinetic parameters in prostate lesions characterization.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2019.07.002
Abstract: PURPOSE To test the potential impact of pharmacokinetic parameters, derived from DCE-MRI analysis, on the diagnostic performance of PI-RADSv.2 classification in prostate lesions characterization. METHOD Among patients who underwent multiparametric prostate MRI (mpMRI) (January 2016-March… read more here.
Keywords: prostate lesions; mri; dce mri; false positive ... See more keywords
Topical Pharmacokinetics of Dexamethasone Suspensions in the Rabbit Eye: Bioavailability Comparison.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2022.121515
Abstract: Topical corticosteroids are used to treat inflammation of the anterior segment. Due to their low water-solubility, they are often formulated as suspensions, but ocular bioavailability of the suspensions is not known. Herein, ocular pharmacokinetics of… read more here.
Keywords: pharmacokinetics dexamethasone; dexamethasone; dexamethasone suspensions; pharmacokinetic parameters ... See more keywords
In Silico Prediction of Human Intravenous Pharmacokinetic Parameters with Improved Accuracy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00300
Abstract: Human pharmacokinetics is of great significance in the selection of drug candidates, and in silico estimation of pharmacokinetic parameters in the early stage of drug development has become the trend of drug research owing to… read more here.
Keywords: prediction human; human intravenous; accuracy; silico prediction ... See more keywords
A method to determine pharmacokinetic parameters based on andante constant-rate intravenous infusion
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13437-6
Abstract: On account of the disturbance from the distribution phase, the concentration-time curve of drugs cannot fully reflect the characteristics of elimination, and thus, it is difficult for present methods to obtain ideal pharmacokinetic parameters. This… read more here.
Keywords: infusion; method determine; rate; pharmacokinetic parameters ... See more keywords
Influence of cyclosporine and everolimus on the main mycophenolate mofetil pharmacokinetic parameters
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000006469
Abstract: Abstract The objective of the present study was to assess the effect of cyclosporine (CsA) on the pharmacokinetic parameters of mycophenolic acid (MPA), an active mycophenolate mofetil (MMF) metabolite, and to compare with the effect… read more here.
Keywords: mmf group; dose mmf; pharmacokinetic parameters; mmf ... See more keywords
Vancomycin pharmacokinetic parameters in patients undergoing hematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Oncology Pharmacy Practice"
DOI: 10.1177/1078155220985317
Abstract: Introduction Current guidelines on vancomycin dosing lack specific recommendations about its dosing in hematopoietic stem cell transplant (HSCT) patients, the objective of the current study was to compare vancomycin pharmacokinetic variables in this population with… read more here.
Keywords: vancomycin pharmacokinetic; pharmacokinetic parameters; population; stem cell ... See more keywords
A brief review of pharmacokinetic assessments of vancomycin in special groups of patients with altered pharmacokinetic parameters.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug safety"
DOI: 10.2174/1574886317666220801124718
Abstract: Vancomycin is considered the drug of choice against many Gram-positive bacterial infections. Therapeutic drug monitoring (TDM) is essential to achieve an optimum clinical response and avoid vancomycin-induced adverse reactions including nephrotoxicity. Although different studies are… read more here.
Keywords: special groups; vancomycin; patients altered; pharmacokinetic assessments ... See more keywords
Comparison of pharmacokinetic parameters of ranolazine between diabetic and non-diabetic rats
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.64391.14156
Abstract: Objective(s): Diabetes mellitus (DM) affects the pharmacokinetics of drugs. Ranolazine is an antianginal drug that is prescribed in DM patients with angina. We decided to evaluate the effect of DM on the pharmacokinetics of ranolazine… read more here.
Keywords: non; parameters ranolazine; ranolazine diabetic; comparison pharmacokinetic ... See more keywords
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite after intravenous administration of increasing doses to sheep.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of veterinary research"
DOI: 10.2460/ajvr.80.7.702
Abstract: OBJECTIVE To determine the pharmacokinetics of pentoxifylline (PTX) and its 5-hydroxyhexyl metabolite (M-I) after IV administration of increasing doses of PTX to sheep. ANIMALS 6 healthy adult Merino sheep. PROCEDURES Each sheep received 10-, 20-,… read more here.
Keywords: administration; hydroxyhexyl metabolite; pharmacokinetics pentoxifylline; administration increasing ... See more keywords
Pharmacokinetic Evaluation and Dosage Optimization of Ketoprofen in Healthy Beetal Goats
Sign Up to like & getrecommendations! Published in 2019 at "Pakistan Veterinary Journal"
DOI: 10.29261/pakvetj/2019.054
Abstract: Received: Revised: Accepted: Published online: February 19, 2019 March 04, 2019 March 12, 2019 April 06, 2019 Ketoprofen (KTP) is a frequently used non-steroidal anti-inflammatory drug (NSAID) in veterinary practice for the treatment of different… read more here.
Keywords: healthy beetal; beetal goats; pharmacokinetic parameters; dosage ... See more keywords