A comprehensive physiologically based pharmacokinetic (PBPK) model for nicotine in humans from using nicotine-containing products with different routes of exposure
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DOI: 10.1038/s41598-022-05108-y
Abstract: Physiologically based pharmacokinetic (PBPK) modeling can be a useful tool for characterizing nicotine pharmacokinetics (PK) from use of tobacco products. We expand a previously published PBPK model to simulate a nicotine PK profile, following single… read more here.
Keywords: pharmacokinetic pbpk; pbpk model; based pharmacokinetic; model ... See more keywords
Therapeutic Drug Monitoring of Vancomycin in Jordanian Patients. Development of Physiologically-Based Pharmacokinetic (PBPK) Model and Validation of Class II Drugs of Salivary Excretion Classification System (SECS).
Sign Up to like & getrecommendations! Published in 2022 at "Drug research"
DOI: 10.1055/a-1852-5391
Abstract: Vancomycin is a commonly used antibiotic for multi-drug resistant gram-positive infections treatment, especially methicillin-resistant Staphylococcus aureus (MRSA). Despite that, it has wide individual pharmacokinetic variability and nephrotoxic effect. Vancomycin trough concentrations for 57 Jordanian patients… read more here.
Keywords: pharmacokinetic pbpk; vancomycin; based pharmacokinetic; jordanian patients ... See more keywords
Development of a physiologically based pharmacokinetic (PBPK) population model for Chinese elderly subjects
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.14609
Abstract: This study aims to develop and verify a physiologically based pharmacokinetic (PBPK) population model for the Chinese geriatric population in Simcyp. read more here.
Keywords: based pharmacokinetic; physiologically based; pbpk population; pharmacokinetic pbpk ... See more keywords
Physiologically Based Pharmacokinetic (PBPK) Modelling for In Vitro-In Vivo Extrapolation: Emphasis on the Use of Dissolution Data
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DOI: 10.14227/dt260319p18
Abstract: Recently the pharmaceutical sector has witnessed a drastic rise in the advancement and incorporation of computerbased technology into several unit operations. Drug dissolution profiling is an important consideration for the successful development of immediate and… read more here.
Keywords: dissolution data; based pharmacokinetic; pbpk modelling; physiologically based ... See more keywords
The Development of a Physiologically Based Pharmacokinetic (PBPK) Model of Andrographolide in Mice and Scaling It up to Rats, Dogs and Humans.
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DOI: 10.2174/1389200223666220628095616
Abstract: BACKGROUND Andrographolide has a potent antiviral effect for the treatment of coronavirus disease (COVID-19). However, there are no in vivo studies of andrographolide as an anti-COVID-19 treatment. OBJECTIVE The study aims to develop a physiologically… read more here.
Keywords: pharmacokinetic pbpk; based pharmacokinetic; pbpk model; physiologically based ... See more keywords
Physiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for metabolic phenotyping with dextromethorphan
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1029073
Abstract: The cytochrome P450 2D6 (CYP2D6) is a key xenobiotic-metabolizing enzyme involved in the clearance of many drugs. Genetic polymorphisms in CYP2D6 contribute to the large inter-individual variability in drug metabolism and could affect metabolic phenotyping… read more here.
Keywords: pharmacokinetic pbpk; metabolic phenotyping; based pharmacokinetic; cyp2d6 ... See more keywords
Current Approaches and Techniques in Physiologically Based Pharmacokinetic (PBPK) Modelling of Nanomaterials
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DOI: 10.3390/nano10071267
Abstract: There have been efforts to develop physiologically based pharmacokinetic (PBPK) models for nanomaterials (NMs). Since NMs have quite different kinetic behaviors, the applicability of the approaches and techniques that are utilized in current PBPK models… read more here.
Keywords: based pharmacokinetic; approaches techniques; physiologically based; pharmacokinetic pbpk ... See more keywords
Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Brain Levels of Drug in Rat
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DOI: 10.3390/pharmaceutics13091402
Abstract: One of the main obstacles in neurological disease treatment is the presence of the blood–brain barrier. New predictive high-throughput screening tools are essential to avoid costly failures in the advanced phases of development and to… read more here.
Keywords: based pharmacokinetic; drug; model; pharmacokinetic pbpk ... See more keywords