Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1‐34) Peptide Fragment
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.2917
Abstract: Polyethylene glycol (PEG) addition can prolong the pharmacokinetic and pharmacodynamic actions of a bioactive peptide in vivo, in part by impeding rates of glomerular filtration. For parathyroid hormone (PTH) peptides, pegylation could help in exploring… read more here.
Keywords: pth; pharmacodynamic actions; peptide; prolonged pharmacokinetic ... See more keywords
Pharmacokinetic and pharmacodynamic considerations of antibiotics and antifungals in liver transplantation recipients
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DOI: 10.1002/lt.26517
Abstract: The liver plays a major role in drug metabolism. Liver transplantation impacts the intrinsic metabolic capability and extrahepatic mechanisms of drug disposition and elimination. Different levels of inflammation and oxidative stress during transplantation, the process… read more here.
Keywords: pharmacokinetic pharmacodynamic; transplantation; considerations antibiotics; transplantation recipients ... See more keywords
ADME: Assessing Pharmacokinetic-Pharmacodynamic Parameters of Oligonucleotides.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9670-4_19
Abstract: We describe tactics to assess pharmacokinetic (PK) and pharmacodynamic (PD) parameters of oligonucleotides. The chapter includes recommendations on the design of single-dose preclinical PK studies, preclinical PKPD studies, and toxicological studies, and on best practice… read more here.
Keywords: parameters oligonucleotides; pharmacodynamic parameters; assessing pharmacokinetic; biology ... See more keywords
The first biosimilar approved for the treatment of osteoporosis: results of a comparative pharmacokinetic/pharmacodynamic study
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DOI: 10.1007/s00198-018-4741-0
Abstract: SummaryTo demonstrate the clinical comparability between RGB-10 (a biosimilar teriparatide) and the originator, a comparative pharmacokinetic trial was conducted. The study was successful in establishing bioequivalence. Marketing authorisation for RGB-10 (Terrosa®) was granted by the… read more here.
Keywords: comparative pharmacokinetic; study; biosimilar approved; pharmacokinetic pharmacodynamic ... See more keywords
Evaluation of pharmacokinetic and pharmacodynamic parameters following single dose of sitagliptin in healthy Indian males
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DOI: 10.1007/s00228-018-2433-5
Abstract: PurposeSitagliptin, a dipeptidyl peptidase (DPP)-IV inhibitor approved for the treatment of type 2 diabetes, is reported to be more efficacious in Indian patients than non-Indian patient population. The objective of the study was to evaluate… read more here.
Keywords: healthy indian; dose sitagliptin; pharmacodynamic parameters; pharmacokinetic pharmacodynamic ... See more keywords
Prolonged infusion of linezolid is associated with improved pharmacokinetic/pharmacodynamic (PK/PD) profiles in patients with external ventricular drains
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-020-02978-x
Abstract: Objective We previously investigated the pharmacokinetic and pharmacodynamic (PK/PD) parameters of routine linezolid infusions (1 h) in patients with external ventricular drains (EVD). The aim of the study was to determine whether extended linezolid infusions… read more here.
Keywords: infusion; prolonged infusion; csf; linezolid infusions ... See more keywords
Deterministic identifiability of population pharmacokinetic and pharmacokinetic–pharmacodynamic models
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-017-9530-4
Abstract: Identifiability is an important component of pharmacokinetic–pharmacodynamic (PKPD) model development. Structural identifiability is concerned with the uniqueness of the model parameters for a set of perfect input–output data and deterministic identifiability with the precision of… read more here.
Keywords: deterministic identifiability; identifiability population; population pharmacokinetic; identifiability ... See more keywords
OptiDose: Computing the Individualized Optimal Drug Dosing Regimen Using Optimal Control
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DOI: 10.1007/s10957-021-01819-w
Abstract: Providing the optimal dosing strategy of a drug for an individual patient is an important task in pharmaceutical sciences and daily clinical application. We developed and validated an optimal dosing algorithm (OptiDose) that computes the… read more here.
Keywords: control; control problem; drug; pharmacokinetic pharmacodynamic ... See more keywords
Pharmacokinetic and Pharmacodynamic Considerations for Drugs Binding to Alpha-1-Acid Glycoprotein
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DOI: 10.1007/s11095-018-2551-x
Abstract: According to the free drug hypothesis only the unbound drug is available to act at physiological sites of action, and as such the importance of plasma protein binding primarily resides in its impact on pharmacokinetics… read more here.
Keywords: alpha acid; acid glycoprotein; drug; pharmacodynamic considerations ... See more keywords
Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat
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DOI: 10.1007/s40262-017-0604-7
Abstract: Oral riociguat is a soluble guanylate cyclase (sGC) stimulator that targets the nitric oxide (NO)–sGC–cyclic guanosine monophosphate pathway with a dual mode of action: directly by stimulating sGC, and indirectly by increasing the sensitivity of… read more here.
Keywords: pharmacodynamic profile; profile riociguat; sgc; pharmacokinetic pharmacodynamic ... See more keywords
Clinical Pharmacokinetics and Pharmacodynamics of Telavancin Compared with the Other Glycopeptides
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DOI: 10.1007/s40262-017-0623-4
Abstract: Telavancin was discovered by modifying the chemical structure of vancomycin and belongs to the group of lipoglycopeptides. It employs its antimicrobial potential through two distinct mechanisms of action: inhibition of bacterial cell wall synthesis and… read more here.
Keywords: clinical pharmacokinetics; telavancin; plasma; soft tissue ... See more keywords